- Targeting the ENKTL pathway in mature NK/T cell malignancy?
- Novel germline mutations causing thrombocytopenia
- High-throughput genetic diagnostic screening for coagulation and platelet disorders
- Review: utility and role of geriatric assessment in the care of patients with hematologic malignancies
- How I treat Waldenström macroglobulinemia
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MELK mediates the stability of EZH2 through site-speciﬁc phosphorylation in extranodal natural killer/T-cell lymphoma
This article describes the interplay between the serine/threonine kinase maternal embryonic leucine zipper kinase (MELK) and the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and provides a basis for targeting this enzymatic pathway in mature natural killer/T-cell malignancies.
The authors provide evidence of a novel association between transcription factor IKZF5, one of the IKAROS family proteins, and thrombocytopenia with decreased alpha granules, thus signiﬁcantly extending our understanding of the gene defects leading to inherited thrombocytopenia.
Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders
This paper reports on the use of a high-throughput diagnostic genetic screening for coagulation, platelet, or thrombotic disorders in a series of more than 2000 patients
Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results
Delivering intensive therapies to older adults with hematologic malignancies: strategies to personalize care
These 2 reviews respectively examine the value and utility of geriatric assessment (GA) tools and discuss the role of GA in the clinical management of patients with hematologic malignancies.
In this How I Treat article on Waldenström macroglobulinemia, the authors present different case-based clinical scenarios and discuss available treatment options.
The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4–positive T cells that are PD-1–negative
The authors provide a topological analysis using multiplex immunoﬂuorescence microscopy to highlight the role of CTLA-4 in the tumor microenvironment of classical Hodgkin lymphoma.