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Blood, 1955, Vol. 10, No. 10, pp. 987-998.
© 1955 American Society of Hematology, Inc.

Studies on Human Myoglobin

II. Fetal Myoglobin: Its Identification and Its Replacement by Adult Myoglobin During Infancy

KARL SINGER 1, BASIL ANGELOPOULOS 1, and BRACHA RAMOT 1

1 Department of Hematologic Research, Medical Research Institute, Michael Reese Hospital, Chicago, Illinois.

Hemoglobin-free met-myoglobin preparations from premature infants and normal newborns contain a fetal type of muscle pigment (Mb F) which differs spectroscopically and electrophoretically from adult myoglobin (Mb A). Acid met-Mb F can not be distinguished from fetal acid met-Hb (Hb F) by these technics. Alkaline met-Mb F has, however, a characteristic absorption spectrum which is dissimilar from that of alkaline met-Hb F, and, electrophoretically, it moves faster than the fetal met-Hb compound. Mb F is gradually replaced by the adult muscle pigment within the first 6 months of life. Thus, the period of disappearance of the fetal red cell pigment from the circulation approximates the period of disappearance of the fetal pigment from the muscle tissue.

Submitted on May 24, 1955
Accepted on June 12, 1955


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