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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by MONTO, R. W. Articles by REBUCK, J. W. Search for Related Content PubMed PubMed Citation Articles by MONTO, R. W. Articles by REBUCK, J. W. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1955, Vol. 10, No. 11, pp. 1151-1155. © 1955 American Society of Hematology, Inc. Observations on the Mechanism of Intranasal Absorption of Vitamin B12 in Pernicious Anemia RAYMOND W. MONTO 1 and JOHN W. REBUCK 1 1 Division of Hematology and the Department of Laboratories, Henry Ford Hospital, Detroit, Michigan. Satisfactory clinical and hematologic response was obtained from the single application to the nasal mucosa of 200 and 150 micrograms of crystalline vitamin B12 in two patients with pernicious anemia. Thirty-two patients with pernicious anemia in relapse and 55 in remission have been controlled satisfactorily by intranasal B12 either in saline solution, lactose powder, or as crystals. Absorption of the vitamin was probably direct and did not require binding with "intrinsic substance." Chronic disease of the nose did not contraindicate this modality of therapy; local irritation of the mucous membranes by the crystalline B12 or the vehicles employed has not been observed. Submitted on December 15, 1954 Accepted on June 22, 1955 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1955 by American Society of Hematology         Online ISSN: 1528-0020