Blood, 1955, Vol. 10, No. 2, pp. 167-175.
© 1955 American Society of Hematology, Inc.
Hemolytic Disease of the Newborn Due to Anti-A1
P. O. HUBINONT 1,
P. LATIERS 1, and
T. MASSART-GUIOT 1
1 Obstetrical Clinic, Paediatric Clinic and Blood Group Laboratory of University Hospital
Saint-Pierre-Brussels, Belgium.
1. The authors report clinical, hematological and serological data in a case of
A1 iso-sensitization of pregnancy.
2. The mother’s serum displayed immune characters specific to A1 cells immediately after delivery. On the 24th day post partum the specificity extended
to A2 cells.
3. The disease exhibited by the infant was very mildly hemolytic. It was
marked by a deep jaundice, repeated alimentary vomiting and a progressive state
of drowsiness. There was no anemia. The direct anti-globulin test was negative.
4. It is shown that the mildness of the hemolytic process in cases of placental
transfer of immune anti-A or anti-B into the incompatible A or B fetus is probably
dependent upon a peculiar "resistance" of the fetal cells. This may be demonstrated in vivo and in vitro. In the present case replacement transfusion with
A1 adult blood resulted in its in vivo sensitization, detectable by the antiglobulin
test and eventually leading to hemolytic anemia.
Submitted on September 28, 1953
Accepted on August 15, 1954
