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Blood, 1955, Vol. 10, No. 3, pp. 235-246.
© 1955 American Society of Hematology, Inc.

Hemoglobin C Disease

Report of Four Cases

WILSON H. HARTZ JR 1 and STEVEN O. SCHWARTZ 1

1 Hematology Laboratory and the Hektoen Institute for Medical Research of the Cook County Hospital.

1. The cases of four Negro patients with splenomegaly and targeting of the red cells are reported.

2. Electrophoretic analysis of the hemoglobin in these cases revealed type C hemoglobin exclusively.

3. An analysis of the genetic, clinical, and hematologic manifestations was made.

4. For convenience, the name hemoglobin C disease has been given to the mild hemolytic syndrome observed in these patients.

5. Electrophoretic recognition of hemoglobin C by filter paper and Tiselius technics is illustrated.

6. Differential diagnosis is discussed with special attention directed to the mild form of Mediterranean anemia.

Submitted on April 23, 1954
Accepted on June 7, 1954


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