Blood, 1955, Vol. 10, No. 3, pp. 252-258.
© 1955 American Society of Hematology, Inc.
Multiple Myelomatosis Treated with a Combination of
Urethane and an Oral Nitrogen Mustard
JAMES INNES 1 and
W. D. RIDER 1
1 Departments of Medicine and Radiotherapy, University of Edinburgh.
1. 17 Cases of advanced multiple myelomatosis have been treated with combined chemotherapy using small doses of urethane and an oral preparation of
nitrogen mustard.
2. The object of such therapy was to test the hypothesis that a synergistic
action existed between these compounds.
3. The results indicate that significant palliation was obtained in many patients treated and that in some the progress of the disease was modified.
4. In the dosage employed such combined therapy appears to be free from
undesirable toxic manifestations and suitable for out-patient administration
over long periods.
Submitted on May 20, 1954
Accepted on July 30, 1954
