Blood, 1955, Vol. 10, No. 4, pp. 351-356.
© 1955 American Society of Hematology, Inc.
Hypoproaccelerinemia
JESSICA H. LEWIS 1 and
JOHN H. FERGUSON 1
1 Department of Physiology, University of North Carolina, Chapel Hill.
This communication is concerned with the case of a 3-year old girl who had
shown a moderately severe bleeding tendency since the age of 6 months. The
cause of the bleeding could be clearly attributed to a marked deficiency in plasma
proaccelerin and platelet accelerator factor. Abnormalities were also found in the
clotting time, prothrombin consumption and Quick test. That this was probably
familial in nature was suggested by moderately reduced plasma proaccelerin
levels in the patients parents and in one sibling.*
Submitted on April 26, 1954
Accepted on July 21, 1954