Blood, 1955, Vol. 10, No. 4, pp. 362-369.
© 1955 American Society of Hematology, Inc.
Studies of Coagulation and Fibrinolysis by New Technic
of Continuous Recording
KURT N. VON KAULLA 1 and
MURRAY WEINER 1
1 Research Service, Third (NYU) Medical Division, Goldwater Memorial Hospital, Welfare Island, New York City, N. Y.
1. The Hartert instrument is a useful tool for recording continuously changes
in a physical property of the clot during its formation and dissolution.
2. Alterations in fibrinogen content, platelets, and plasma clotting factors influence the pattern of the coagulogram. These patterns do not necessarily parallel
the results of classical clotting time studies based on observation of the time
necessary to form a visible clot. Clearly visible clots may not be sufficiently firm
to be recorded by the coagulograph.
3. Coagulograph studies require careful handling of blood specimens to avoid
artefacts of extrinsic origin.
4. The lysis of clots by different enzymes follows significantly different patterns
which are not detectable by the standard methods for observing the dissolution
of a clot.
Submitted on June 1, 1954
Accepted on August 14, 1954
