Blood, 1955, Vol. 10, No. 6, pp. 612-615.
© 1955 American Society of Hematology, Inc.
In Vitro Studies of Erythropoiesis
II. The Effect of Anoxia on Heme Synthesis
E. D. THOMAS 1
1 Department of Medicine, Harvard Medical School, the Medical Clinic, Peter
Bent Brigham Hospital, and the Children’s Cancer Research Foundation, Children’s
Medical Center, Boston.
The effect of various oxygen tensions on the in vitro synthesis of heme by rabbit bone marrow was measured. At levels above 4 per cent oxygen there was no
effect of oxygen tension on heme synthesis. Total anoxia stopped heme synthesis
completely. No level of oxygen tension was found to stimulate heme synthesis.
Submitted on November 16, 1954
Accepted on January 1, 1955
