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Blood, 1 July 2002, Vol. 100, No. 1, pp. 238-245
NEOPLASIA
Bethesda proposals for classification of nonlymphoid
hematopoietic neoplasms in mice
Scott C. Kogan,
Jerrold M. Ward,
Miriam R. Anver,
Jules J. Berman,
Cory Brayton,
Robert D. Cardiff,
John S. Carter,
Sherri de
Coronado,
James R. Downing,
Torgny N. Fredrickson,
Diana C. Haines,
Alan W. Harris,
Nancy Lee Harris,
Hiroshi Hiai,
Elaine S. Jaffe,
Ian C. M. MacLennan,
Pier Paolo Pandolfi,
Paul K. Pattengale,
Archibald S. Perkins,
R. Mark Simpson,
Mark S. Tuttle,
Joanne F. Wong, and
Herbert C. Morse III
From the Comprehensive Cancer Center and Department of
Laboratory Medicine, University of California, San Francisco; Apelon,
Inc., Alameda, CA; Center for Comparative Medicine and Department of
Pathology, University of California, Davis; and Department of
Pathology, Children's Hospital of Los Angeles; CA; Center for
Comparative Medicine, Baylor College of Medicine, Houston, TX;
Department of Pathology and Biology of Diseases, Kyoto University
Graduate School of Medicine, Japan; Department of Pathology,
Massachusetts General Hospital, Boston; Molecular Biology Program and
Department of Pathology, Memorial Sloan-Kettering Cancer Center,
Cornell University, New York, NY; Cancer Diagnosis Program, Center for
Bioinformatics, and Laboratory of Pathology, National Cancer Institute,
Bethesda, MD; Laboratory of Immunopathology, National Institute of
Allergy and Infectious Diseases, Bethesda, MD; Veterinary and Tumor
Pathology Section and SAIC, National Cancer Institute, Frederick, MD;
and Infectious Disease Pathogenesis Branch, National Institute of
Allergy and Infectious Diseases, Rockville, MD; Department of
Pathology, St Jude Children's Research Hospital, Memphis, TN; Medical
Research Council Centre for Immune Regulation, University of Birmingham
Medical School, Birmingham, United Kingdom; Walter and Eliza Hall
Institute of Medical Research, Royal Melbourne Hospital, Victoria,
Australia; and Department of Pathology, Yale University, New Haven, CT.
The hematopathology subcommittee of the Mouse Models of Human
Cancers Consortium recognized the need for a classification of murine
hematopoietic neoplasms that would allow investigators to diagnose
lesions as well-defined entities according to accepted criteria.
Pathologists and investigators worked cooperatively to develop
proposals for the classification of lymphoid and nonlymphoid hematopoietic neoplasms. It is proposed here that nonlymphoid hematopoietic neoplasms of mice be classified in 4 broad categories: nonlymphoid leukemias, nonlymphoid hematopoietic sarcomas, myeloid dysplasias, and myeloid proliferations (nonreactive). Criteria for
diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues,
histopathology, immunophenotyping, genetic features, and clinical
course. Differences between murine and human lesions are reflected in
the terminology and methods used for classification. This
classification will be of particular value to investigators seeking to
develop, use, and communicate about mouse models of human hematopoietic neoplasms.
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