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Blood, 1 July 2002, Vol. 100, No. 1, pp. 246-258
NEOPLASIA
Bethesda proposals for classification of lymphoid neoplasms
in mice
Herbert C. Morse III,
Miriam R. Anver,
Torgny N. Fredrickson,
Diana C. Haines,
Alan W. Harris,
Nancy L. Harris,
Elaine S. Jaffe,
Scott C. Kogan,
Ian C. M. MacLennan,
Paul K. Pattengale, and
Jerrold M. Ward
From the Laboratory of Immunopathology, National
Institute of Allergy and Infectious Diseases, the Hematopathology
Section, Laboratory of Pathology, National Cancer Institute, National
Institutes of Health, Bethesda, MD; the Pathology/Histotechnology
Laboratory, SAIC-Frederick, the Veterinary and Tumor Pathology Section,
Center for Cancer Research, National Cancer Institute at Frederick,
National Institutes of Health, Frederick, MD; the Walter and Eliza Hall
Institute of Medical Research, Melbourne, Victoria, Australia; the
Department of Pathology, Massachusetts General Hospital, Boston, MA;
the Department of Laboratory Medicine, University of California, San
Francisco; Children's Hospital of Los Angeles, CA; and the University
of Birmingham Medical School, Birmingham, United Kingdom.
A consensus system for classification of mouse lymphoid neoplasms
according to their histopathologic and genetic features has been an
elusive target for investigators involved in understanding the
pathogenesis of spontaneous cancers or modeling human hematopoietic diseases in mice. An international panel of scientists with expertise in mouse and human hematopathology joined with the hematopathology subcommittee of the Mouse Models for Human Cancers Consortium to
develop criteria for definition and classification of these diseases
together with a standardized nomenclature. The fundamental elements
contributing to the scheme are clinical features, morphology, immunophenotype, and genetic characteristics. The resulting
classification has numerous parallels to the World Health Organization
classification of human lymphoid tumors while recognizing differences
that may be species specific. The classification should facilitate
communications about mouse models of human lymphoid diseases.

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