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Blood, 1 July 2002, Vol. 100, No. 1, pp. 246-258

NEOPLASIA

Bethesda proposals for classification of lymphoid neoplasms in mice

Herbert C. Morse III, Miriam R. Anver, Torgny N. Fredrickson, Diana C. Haines, Alan W. Harris, Nancy L. Harris, Elaine S. Jaffe, Scott C. Kogan, Ian C. M. MacLennan, Paul K. Pattengale, and Jerrold M. Ward

From the Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, the Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD; the Pathology/Histotechnology Laboratory, SAIC-Frederick, the Veterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD; the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; the Department of Pathology, Massachusetts General Hospital, Boston, MA; the Department of Laboratory Medicine, University of California, San Francisco; Children's Hospital of Los Angeles, CA; and the University of Birmingham Medical School, Birmingham, United Kingdom.

A consensus system for classification of mouse lymphoid neoplasms according to their histopathologic and genetic features has been an elusive target for investigators involved in understanding the pathogenesis of spontaneous cancers or modeling human hematopoietic diseases in mice. An international panel of scientists with expertise in mouse and human hematopathology joined with the hematopathology subcommittee of the Mouse Models for Human Cancers Consortium to develop criteria for definition and classification of these diseases together with a standardized nomenclature. The fundamental elements contributing to the scheme are clinical features, morphology, immunophenotype, and genetic characteristics. The resulting classification has numerous parallels to the World Health Organization classification of human lymphoid tumors while recognizing differences that may be species specific. The classification should facilitate communications about mouse models of human lymphoid diseases.

© 2002 by The American Society of Hematology.
 

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