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Blood, 1 July 2002, Vol. 100, No. 1, pp. 344-346

BRIEF REPORT

Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia

Stephen F. Garner, Kate Campbell, Paul Metcalfe, Jane Keidan, Elly Huiskes, Jing-Fei Dong, José A. López, and Willem H. Ouwehand

From the Division of Transfusion Medicine, University of Cambridge and National Blood Service East Anglia Centre, United Kingdom; National Institute for Biological Standards and Control, Potters Bar; Queen Elizabeth NHS Trust Hospital, King's Lynn, United Kingdom; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands; and Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX.

Autoimmune thrombocytopenia is generally caused by autoantibodies against glycoprotein (GP) IIb-IIIa or GPIb-IX and occasionally against GPIa-IIa or GPV. By investigating 38 rheumatoid arthritis (RA) patients on gold therapy, 10 with profound thrombocytopenia and 28 nonthrombocytopenic controls, we showed that in all 10 patients with thrombocytopenia, the platelet autoantibodies preferentially targeted GPV but the presence of gold was not required for their reactivity. Elevated levels of platelet-associated IgG (PAIgG) were observed in 8 of the 10 patients in whom the tests were performed. In 5 patients with sufficient autologous platelets, the GPV specificity of PAIgG was confirmed. Tests with GPV transfectants revealed that the antibodies reacted with GPV independent of GPIbalpha , GPIbbeta , or GPIX. Autoantibodies recognizing GPV were not seen in the 28 nonthrombocytopenic control RA patients. Thus, GPV seems to be targeted in gold-induced autoimmune thrombocytopenia.

© 2002 by The American Society of Hematology.
 

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