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Prepublished online as a Blood First Edition Paper on April 17, 2002; DOI 10.1182/blood-2002-01-0144.
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Blood, 1 July 2002, Vol. 100, No. 1, pp. 347-349
BRIEF REPORT
Nondisjunction of chromosomes leading to hyperdiploid
childhood B-cell precursor acute lymphoblastic leukemia is an
early event during leukemogenesis
E. Renate Panzer-Grümayer,
Karin Fasching,
Simon Panzer,
Klaudia Hettinger,
Klaus Schmitt,
Sylvia Stöckler-Ipsiroglu, and
Oskar A. Haas
From the Children's Cancer Research Institute; St Anna
Kinderspital; Clinic for Blood Group Serology, University of Vienna;
Landeskinderkrankenhaus Linz; and Austrian Newborn Screening
Laboratory, Department of Pediatrics, University of Vienna; all of
Austria.
A hyperdiploid karyotype is found in 30% of B-cell precursor acute
lymphoblastic leukemias in childhood. The time of nondisjunction of
chromosomes leading to hyperdiploidy during leukemogenesis is unknown.
We used the 3 clonotypic immunoglobulin heavy chain (IgH) gene
rearrangements as molecular markers for each of the 3 chromosomes 14 in
a case with hyperdiploid acute lymphoblastic leukemia to define the
order of events namely, somatic recombination and nondisjunction of
chromosomesduring leukemia development. A partial sequence homology
of the incomplete DJH rearrangement with 1 of the 2 nonfunctional VDJH rearrangements suggests that the
doubling of chromosomes had occurred after this DJH
rearrangement and thus during early B-cell differentiation. The
occurrence of the nondisjunction of chromosomes as well as ongoing
rearrangement processes in utero were confirmed by the presence of all
3 IgH rearrangements in neonatal blood spots, providing the first
evidence that hyperdiploidy formation is an early event in
leukemogenesis in these leukemias.
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