SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on April 30, 2002; DOI 10.1182/blood-2001-12-0276. This Article Full Text Full Text (PDF) All Versions of this Article: 2001-12-0276v1 100/1/350    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ronchetti, S. Articles by Pandolfi, P. P. Search for Related Content PubMed PubMed Citation Articles by Ronchetti, S. Articles by Pandolfi, P. P. Related Collections Immunobiology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 July 2002, Vol. 100, No. 1, pp. 350-352 BRIEF REPORT Role of GITR in activation response of T lymphocytes Simona Ronchetti, Giuseppe Nocentini, Carlo Riccardi, and Pier Paolo Pandolfi From the Department of Clinical and Experimental Medicine, Section of Pharmacology, Perugia University Medical School, Italy; and Molecular Biology Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY. In this study, we describe the generation and characterization of mice in which GITR gene (TNFRSF18 [tumor necrosis factor receptor superfamily 18]), a member of the TNFRSF expressed mainly on T lymphocytes, has been ablated (GITR/ mice). Results indicate that GITR inactivation does not impair the normal development of the lymphoid organs but modulates T-cell activation. In fact, when GITR/ T lymphocytes are activated by treatment with an anti-CD3 monoclonal antibody they proliferate more than wild-type cells. Moreover, activated GITR/ T lymphocytes express higher levels of interleukin-2 receptor, produce larger amounts of interleukin-2, and are more sensitive to activation-induced cell death than controls. These results suggest that GITR is involved in the regulation of T-cell receptor/CD3-driven T-cell activation and programmed cell death. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Nocentini, S. Cuzzocrea, T. Genovese, R. Bianchini, E. Mazzon, S. Ronchetti, E. Esposito, D. P. Rosanna, P. Bramanti, and C. Riccardi Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related (GITR)-Fc Fusion Protein Inhibits GITR Triggering and Protects from the Inflammatory Response after Spinal Cord Injury Mol. Pharmacol., June 1, 2008; 73(6): 1610 - 1621. [Abstract] [Full Text] [PDF] M. E. C. Lutsiak, Y. Tagaya, A. J. Adams, J. Schlom, and H. Sabzevari Tumor-Induced Impairment of TCR Signaling Results in Compromised Functionality of Tumor-Infiltrating Regulatory T Cells J. Immunol., May 1, 2008; 180(9): 5871 - 5881. [Abstract] [Full Text] [PDF] B. Liu, Z. Li, S. P. Mahesh, S. Pantanelli, F. S. Hwang, W. O. Siu, and R. B. Nussenblatt Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis J. Biol. Chem., March 28, 2008; 283(13): 8202 - 8210. [Abstract] [Full Text] [PDF] S. Ronchetti, G. Nocentini, R. Bianchini, L. T. Krausz, G. Migliorati, and C. Riccardi Glucocorticoid-Induced TNFR-Related Protein Lowers the Threshold of CD28 Costimulation in CD8+ T Cells J. Immunol., November 1, 2007; 179(9): 5916 - 5926. [Abstract] [Full Text] [PDF] S. Tuyaerts, S. Van Meirvenne, A. Bonehill, C. Heirman, J. Corthals, H. Waldmann, K. Breckpot, K. Thielemans, and J. L. Aerts Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells J. Leukoc. Biol., July 1, 2007; 82(1): 93 - 105. [Abstract] [Full Text] [PDF] C. Hubeau, I. Apostolou, and L. Kobzik Targeting of CD25 and Glucocorticoid-Induced TNF Receptor Family-Related Gene-Expressing T Cells Differentially Modulates Asthma Risk in Offspring of Asthmatic and Normal Mother Mice J. Immunol., February 1, 2007; 178(3): 1477 - 1487. [Abstract] [Full Text] [PDF] L Santucci, M Agostini, S Bruscoli, A Mencarelli, S Ronchetti, E Ayroldi, A Morelli, M Baldoni, and C Riccardi GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice Gut, January 1, 2007; 56(1): 52 - 60. [Abstract] [Full Text] [PDF] S. Cuzzocrea, S. Ronchetti, T. Genovese, E. Mazzon, M. Agostini, R. Di Paola, E. Esposito, C. Muia, G. Nocentini, and C. Riccardi Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation FASEB J, January 1, 2007; 21(1): 117 - 129. [Abstract] [Full Text] [PDF] J. E. Korf, G. Pynaert, K. Tournoy, T. Boonefaes, A. Van Oosterhout, D. Ginneberge, A. Haegeman, J. A. Verschoor, P. De Baetselier, and J. Grooten Macrophage Reprogramming by Mycolic Acid Promotes a Tolerogenic Response in Experimental Asthma Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 152 - 160. [Abstract] [Full Text] [PDF] S. Cuzzocrea, G. Nocentini, R. Di Paola, M. Agostini, E. Mazzon, S. Ronchetti, C. Crisafulli, E. Esposito, A. P. Caputi, and C. Riccardi Proinflammatory Role of Glucocorticoid-Induced TNF Receptor-Related Gene in Acute Lung Inflammation J. Immunol., July 1, 2006; 177(1): 631 - 641. [Abstract] [Full Text] [PDF] A. D. Cohen, A. Diab, M.-A. Perales, J. D. Wolchok, G. Rizzuto, T. Merghoub, D. Huggins, C. Liu, M. J. Turk, N. P. Restifo, et al. Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity. Cancer Res., May 1, 2006; 66(9): 4904 - 4912. [Abstract] [Full Text] [PDF] S. J. Robertson, R. J. Messer, A. B. Carmody, and K. J. Hasenkrug In Vitro Suppression of CD8+ T Cell Function by Friend Virus-Induced Regulatory T Cells J. Immunol., March 15, 2006; 176(6): 3342 - 3349. [Abstract] [Full Text] [PDF] H. J. Kim, H. Y. Kim, B. K. Kim, S. Kim, and D. H. Chung Engagement of Glucocorticoid-Induced TNF Receptor Costimulates NKT Cell Activation In Vitro and In Vivo J. Immunol., March 15, 2006; 176(6): 3507 - 3515. [Abstract] [Full Text] [PDF] J. Wang, V. Devgan, M. Corrado, N. S. Prabhu, W. S. El-Deiry, C. Riccardi, P. P. Pandolfi, C. Missero, and G. P. Dotto Glucocorticoid-induced Tumor Necrosis Factor Receptor Is a p21Cip1/WAF1 Transcriptional Target Conferring Resistance of Keratinocytes to UV Light-induced Apoptosis J. Biol. Chem., November 11, 2005; 280(45): 37725 - 37731. [Abstract] [Full Text] [PDF] M. Agostini, E. Cenci, E. Pericolini, G. Nocentini, G. Bistoni, A. Vecchiarelli, and C. Riccardi The Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related Gene Modulates the Response to Candida albicans Infection Infect. Immun., November 1, 2005; 73(11): 7502 - 7508. [Abstract] [Full Text] [PDF] S. Cuzzocrea, E. Ayroldi, R. Di Paola, M. Agostini, E. Mazzon, S. Bruscoli, T. Genovese, S. Ronchetti, A. P. Caputi, and C. Riccardi Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis FASEB J, August 1, 2005; 19(10): 1253 - 1265. [Abstract] [Full Text] [PDF] L.-F. Lu, D. C. Gondek, Z. A. Scott, and R. J. Noelle NF{kappa}B-Inducing Kinase Deficiency Results in the Development of a Subset of Regulatory T Cells, which Shows a Hyperproliferative Activity upon Glucocorticoid-Induced TNF Receptor Family-Related Gene Stimulation J. Immunol., August 1, 2005; 175(3): 1651 - 1657. [Abstract] [Full Text] [PDF] E. M. Esparza and R. H. Arch Glucocorticoid-Induced TNF Receptor Functions as a Costimulatory Receptor That Promotes Survival in Early Phases of T Cell Activation J. Immunol., June 15, 2005; 174(12): 7869 - 7874. [Abstract] [Full Text] [PDF] B. Valzasina, C. Guiducci, H. Dislich, N. Killeen, A. D. Weinberg, and M. P. Colombo Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR Blood, April 1, 2005; 105(7): 2845 - 2851. [Abstract] [Full Text] [PDF] H.-M. van Santen, C. Benoist, and D. Mathis Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells J. Exp. Med., November 15, 2004; 200(10): 1221 - 1230. [Abstract] [Full Text] [PDF] H. He, R. J. Messer, S. Sakaguchi, G. Yang, S. J. Robertson, and K. J. Hasenkrug Reduction of Retrovirus-Induced Immunosuppression by In Vivo Modulation of T Cells during Acute Infection J. Virol., November 1, 2004; 78(21): 11641 - 11647. [Abstract] [Full Text] [PDF] G. L. Stephens, R. S. McHugh, M. J. Whitters, D. A. Young, D. Luxenberg, B. M. Carreno, M. Collins, and E. M. Shevach Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells J. Immunol., October 15, 2004; 173(8): 5008 - 5020. [Abstract] [Full Text] [PDF] B. J. Kim, Z. Li, R. N. Fariss, D. F. Shen, S. P. Mahesh, C. Egwuagu, C.-R. Yu, C. N. Nagineni, C.-C. Chan, and R. B. Nussenblatt Constitutive and Cytokine-Induced GITR Ligand Expression on Human Retinal Pigment Epithelium and Photoreceptors Invest. Ophthalmol. Vis. Sci., September 1, 2004; 45(9): 3170 - 3176. [Abstract] [Full Text] [PDF] Y. Zhan, D. P. Funda, A. L. Every, P. Fundova, J. F. Purton, D. R. Liddicoat, T. J. Cole, D. I. Godfrey, J. L. Brady, S. I. Mannering, et al. TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death Int. Immunol., September 1, 2004; 16(9): 1315 - 1321. [Abstract] [Full Text] [PDF] S. J. Muriglan, T. Ramirez-Montagut, O. Alpdogan, T. W. van Huystee, J. M. Eng, V. M. Hubbard, A. A. Kochman, K. H. Tjoe, C. Riccardi, P. P. Pandolfi, et al. GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease J. Exp. Med., July 19, 2004; 200(2): 149 - 157. [Abstract] [Full Text] [PDF] F. Kanamaru, P. Youngnak, M. Hashiguchi, T. Nishioka, T. Takahashi, S. Sakaguchi, I. Ishikawa, and M. Azuma Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells J. Immunol., June 15, 2004; 172(12): 7306 - 7314. [Abstract] [Full Text] [PDF] K. Uraushihara, T. Kanai, K. Ko, T. Totsuka, S. Makita, R. Iiyama, T. Nakamura, and M. Watanabe Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25- CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells J. Immunol., July 15, 2003; 171(2): 708 - 716. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020