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Prepublished online as a Blood First Edition Paper on April 17, 2002; DOI 10.1182/blood-2002-01-0128.
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Blood, 1 July 2002, Vol. 100, No. 1, pp. 353-355
BRIEF REPORT
Influence of plasma immunoglobulin level on antibody
synthesis
Andreas Goldammer,
Kurt Derfler,
Kurt Herkner,
Arthur R. Bradwell,
Walter H. Hörl, and
Martin Haas
From the Department of Internal Medicine III, Division
of Nephrology and Dialysis, and Department of Pediatric Laboratory
Medicine, University Hospital Vienna, Austria; and the Department of
Immunology, The Medical School, University of Birmingham, England.
In previous experimental animal studies it has been
demonstrated that antibody depletion is not followed by increased
antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as
markers of current antibody synthesis in 8 patients treated with
immunoadsorption (IA) therapy. Specific and bulk immunoglobulin levels
were obtained simultaneously. The mean serum flc concentration increased to the preapheresis value within 1 day and remained unchanged
thereafter. Total immunoglobulin G (IgG) and specific antibody
concentrations increased to pretreatment values in 88% and 43% of the
patients, respectively, and remained below the original values in the
others. In conclusion, the lack of increased flc synthesis after IA
confirms the absence of a feedback mechanism regulating antibody
synthesis. The restoration of serum IgG levels after IA, therefore,
does not result from increased antibody synthesis but is probably
related to changes of catabolism and immunoglobulin backflow.
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