SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on July 12, 2002; DOI 10.1182/blood-2002-01-0108. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-01-0108v1 100/10/3484    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Prandoni, P. Articles by Girolami, A. Search for Related Content PubMed PubMed Citation Articles by Prandoni, P. Articles by Girolami, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 November 2002, Vol. 100, No. 10, pp. 3484-3488 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis Paolo Prandoni, Anthonie W. A. Lensing, Andrea Piccioli, Enrico Bernardi, Paolo Simioni, Bruno Girolami, Antonio Marchiori, Paola Sabbion, Martin H. Prins, Franco Noventa, and Antonio Girolami From the Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, and the Department of Clinical and Experimental Medicine, Clinical Epidemiology Group, Fifth Chair of Internal Medicine, University Hospital of Padua, Italy; and Center for Vascular Medicine and the Department of Clinical Epidemiology, Academic Medical Center, University of Amsterdam, The Netherlands. A small proportion of patients with deep vein thrombosis develop recurrent venous thromboembolic complications or bleeding during anticoagulant treatment. These complications may occur more frequently if these patients have concomitant cancer. This prospective follow-up study sought to determine whether in thrombosis patients those with cancer have a higher risk for recurrent venous thromboembolism or bleeding during anticoagulant treatment than those without cancer. Of the 842 included patients, 181 had known cancer at entry. The 12-month cumulative incidence of recurrent thromboembolism in cancer patients was 20.7% (95% CI, 15.6%-25.8%) versus 6.8% (95% CI, 3.9%- 9.7%) in patients without cancer, for a hazard ratio of 3.2 (95% CI, 1.9-5.4) The 12-month cumulative incidence of major bleeding was 12.4% (95% CI, 6.5%-18.2%) in patients with cancer and 4.9% (95% CI, 2.5%-7.4%) in patients without cancer, for a hazard ratio of 2.2 (95% CI, 1.2-4.1). Recurrence and bleeding were both related to cancer severity and occurred predominantly during the first month of anticoagulant therapy but could not be explained by sub- or overanticoagulation. Cancer patients with venous thrombosis are more likely to develop recurrent thromboembolic complications and major bleeding during anticoagulant treatment than those without malignancy. These risks correlate with the extent of cancer. Possibilities for improvement using the current paradigms of anticoagulation seem limited and new treatment strategies should be developed. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. W. Francis Prevention of Venous Thromboembolism in Hospitalized Patients With Cancer J. Clin. Oncol., October 10, 2009; 27(29): 4874 - 4880. [Abstract] [Full Text] [PDF] A. A. Khorana, M. B. Streiff, D. Farge, M. Mandala, P. Debourdeau, F. Cajfinger, M. Marty, A. Falanga, and G. H. Lyman Venous Thromboembolism Prophylaxis and Treatment in Cancer: A Consensus Statement of Major Guidelines Panels and Call to Action J. Clin. Oncol., October 10, 2009; 27(29): 4919 - 4926. [Abstract] [Full Text] [PDF] A. Y.Y. Lee Anticoagulation in the Treatment of Established Venous Thromboembolism in Patients With Cancer J. Clin. Oncol., October 10, 2009; 27(29): 4895 - 4901. [Abstract] [Full Text] [PDF] G. H. Lyman and A. A. Khorana Cancer, Clots and Consensus: New Understanding of an Old Problem J. Clin. Oncol., October 10, 2009; 27(29): 4821 - 4826. [Full Text] [PDF] A. A. Khorana Cancer and thrombosis: implications of published guidelines for clinical practice Ann. Onc., October 1, 2009; 20(10): 1619 - 1630. [Abstract] [Full Text] [PDF] C. Ay, R. Vormittag, D. Dunkler, R. Simanek, A.-L. Chiriac, J. Drach, P. Quehenberger, O. Wagner, C. Zielinski, and I. Pabinger D-Dimer and Prothrombin Fragment 1 + 2 Predict Venous Thromboembolism in Patients With Cancer: Results From the Vienna Cancer and Thrombosis Study J. Clin. Oncol., September 1, 2009; 27(25): 4124 - 4129. [Abstract] [Full Text] [PDF] G. H Lyman Preventing Venous Thromboembolism in Cancer Patients: Can We Do Better? J. Oncol. Pract, July 1, 2009; 5(4): 165 - 166. [Full Text] [PDF] M. F. Barginear, M. Lesser, M. L. Akerman, M. Strakhan, I. Shapira, T. Bradley, and D. R. Budman Need for Inferior Vena Cava Filters in Cancer Patients: A Surrogate Marker for Poor Outcome Clinical and Applied Thrombosis/Hemostasis, June 1, 2009; 15(3): 263 - 269. [Abstract] [PDF] T. Zhu, I. Martinez, and J. Emmerich Venous Thromboembolism: Risk Factors for Recurrence Arterioscler Thromb Vasc Biol, March 1, 2009; 29(3): 298 - 310. [Abstract] [Full Text] [PDF] T. Sousou and A. A. Khorana New Insights Into Cancer-Associated Thrombosis Arterioscler Thromb Vasc Biol, March 1, 2009; 29(3): 316 - 320. [Abstract] [Full Text] [PDF] B. BABU and T. L. CARMAN Cancer and clots: All cases of venous thromboembolism are not treated the same Cleveland Clinic Journal of Medicine, February 1, 2009; 76(2): 129 - 135. [Abstract] [Full Text] [PDF] A. A. Khorana and G. H. Lyman Incidence and Prevention of Cancer-associated Thrombosis ASCO Educational Book, January 1, 2009; 2009(1): 321 - 325. [Abstract] [Full Text] [PDF] A. Y.Y. Lee Treatment of Venous Thromboembolism in Patients with Cancer ASCO Educational Book, January 1, 2009; 2009(1): 331 - 336. [Abstract] [Full Text] [PDF] D. O. Claassen, N. Kazemi, A. Y. Zubkov, E. F. M. Wijdicks, and A. A. Rabinstein Restarting Anticoagulation Therapy After Warfarin-Associated Intracerebral Hemorrhage Arch Neurol, October 1, 2008; 65(10): 1313 - 1318. [Abstract] [Full Text] [PDF] C. Ay, R. Simanek, R. Vormittag, D. Dunkler, G. Alguel, S. Koder, G. Kornek, C. Marosi, O. Wagner, C. Zielinski, et al. High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS) Blood, October 1, 2008; 112(7): 2703 - 2708. [Abstract] [Full Text] [PDF] M. Carrier, G. Le Gal, P. S. Wells, D. Fergusson, T. Ramsay, and M. A. Rodger Systematic Review: The Trousseau Syndrome Revisited: Should We Screen Extensively for Cancer in Patients with Venous Thromboembolism? Ann Intern Med, September 2, 2008; 149(5): 323 - 333. [Abstract] [Full Text] [PDF] P. Prandoni, J. Trujillo-Santos, T. Surico, F. D. Valle, A. Piccioli, M. Monreal, and for the RIETE Investigators Recurrent thromboembolism and major bleeding during oral anticoagulant therapy in patients with solid cancer: findings from the RIETE registry Haematologica, September 1, 2008; 93(9): 1432 - 1434. [Full Text] [PDF] S. Schulman, R. J. Beyth, C. Kearon, and M. N. Levine Hemorrhagic Complications of Anticoagulant and Thrombolytic Treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 257S - 298S. [Abstract] [Full Text] [PDF] W. H. Geerts, D. Bergqvist, G. F. Pineo, J. A. Heit, C. M. Samama, M. R. Lassen, and C. W. Colwell Prevention of Venous Thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 381S - 453S. [Abstract] [Full Text] [PDF] C. J. M. Doggen Thromboprophylaxis in cancer outpatients Blood, May 15, 2008; 111(10): 4833 - 4833. [Full Text] [PDF] A. A. Khorana, N. M. Kuderer, E. Culakova, G. H. Lyman, and C. W. Francis Development and validation of a predictive model for chemotherapy-associated thrombosis Blood, May 15, 2008; 111(10): 4902 - 4907. [Abstract] [Full Text] [PDF] D. Imberti, G. Agnelli, W. Ageno, M. Moia, G. Palareti, R. Pistelli, R. Rossi, M. Verso, and for the MASTER Investigators Clinical characteristics and management of cancer-associated acute venous thromboembolism: findings from the MASTER Registry Haematologica, February 1, 2008; 93(2): 273 - 278. [Abstract] [Full Text] [PDF] F. J. Munoz, P. Mismetti, R. Poggio, R. Valle, M. Barron, M. Guil, M. Monreal, and for the RIETE Investigators Clinical Outcome of Patients With Upper-Extremity Deep Vein Thrombosis: Results From the RIETE Registry,{dagger} Chest, January 1, 2008; 133(1): 143 - 148. [Abstract] [Full Text] [PDF] A. A. Khorana, H. A. Liebman, R. H. White, T. Wun, and G. H. Lyman The Risk of Venous Thromboembolism in Patients with Cancer ASCO Educational Book, January 1, 2008; 2008(1): 240 - 248. [Abstract] [Full Text] [PDF] A. Falanga, A. Y. Y. Lee, M. B. Streiff, and G. H. Lyman Anticoagulation in the Treatment of Venous Thromboembolism in Patients with Cancer ASCO Educational Book, January 1, 2008; 2008(1): 258 - 268. [Abstract] [Full Text] [PDF] G. H. Lyman, A. A. Khorana, A. Falanga, D. Clarke-Pearson, C. Flowers, M. Jahanzeb, A. Kakkar, N. M. Kuderer, M. N. Levine, H. Liebman, et al. American Society of Clinical Oncology Guideline: Recommendations for Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer J. Clin. Oncol., December 1, 2007; 25(34): 5490 - 5505. [Abstract] [Full Text] [PDF] A. A. Khorana The NCCN Clinical Practice Guidelines on Venous Thromboembolic Disease: Strategies for Improving VTE Prophylaxis in Hospitalized Cancer Patients Oncologist, November 1, 2007; 12(11): 1361 - 1370. [Abstract] [Full Text] [PDF] J. Nishioka and S. Goodin Low-molecular-weight heparin in cancer-associated thrombosis: treatment, secondary prevention, and survival Journal of Oncology Pharmacy Practice, June 1, 2007; 13(2): 85 - 97. [Abstract] [PDF] R. De Caterina, S. Husted, L. Wallentin, G. Agnelli, F. Bachmann, C. Baigent, J. Jespersen, S. D. Kristensen, G. Montalescot, A. Siegbahn, et al. Anticoagulants in heart disease: current status and perspectives Eur. Heart J., April 10, 2007; (2007) ehl492v1. [Full Text] [PDF] K. C. Stine, R. L. Saylors, C. Suzanne Saccente, and D. L. Becton Treatment of Deep Vein Thrombosis With Enoxaparin in Pediatric Cancer Patients Receiving Chemotherapy Clinical and Applied Thrombosis/Hemostasis, April 1, 2007; 13(2): 161 - 165. [Abstract] [PDF] G. Ferretti, E. Bria, D. Giannarelli, P. Carlini, A. Felici, M. Mandala, P. Papaldo, A. Fabi, M. Ciccarese, F. Cuppone, et al. Is Recurrent Venous Thromboembolism After Therapy Reduced by Low-Molecular-Weight Heparin Compared With Oral Anticoagulants? Chest, December 1, 2006; 130(6): 1808 - 1816. [Abstract] [Full Text] [PDF] D. Scarvelis and P. S. Wells Diagnosis and treatment of deep-vein thrombosis. Can. Med. Assoc. J., October 24, 2006; 175(9): 1087 - 1092. [Abstract] [Full Text] [PDF] C. Schunn, G. B. Schunn, G. Hobbs, L. C. Vona-Davis, and U. Waheed Inferior Vena Cava Filter Placement in Late-Stage Cancer Vascular and Endovascular Surgery, August 1, 2006; 40(4): 287 - 294. [Abstract] [PDF] D. E. Gerber, S. A. Grossman, and M. B. Streiff Management of Venous Thromboembolism in Patients With Primary and Metastatic Brain Tumors J. Clin. Oncol., March 10, 2006; 24(8): 1310 - 1318. [Abstract] [Full Text] [PDF] P. Prandoni How I treat venous thromboembolism in patients with cancer Blood, December 15, 2005; 106(13): 4027 - 4033. [Abstract] [Full Text] [PDF] M. N. Levine, A. Y.Y. Lee, and A. K. Kakkar In Reply: J. Clin. Oncol., October 1, 2005; 23(28): 7250 - 7250. [Full Text] [PDF] J. Trujillo-Santos, E. Perea-Milla, A. Jimenez-Puente, E. Sanchez-Cantalejo, J. del Toro, E. Grau, M. Monreal, and for the RIETE Investigators Bed Rest or Ambulation in the Initial Treatment of Patients With Acute Deep Vein Thrombosis or Pulmonary Embolism: Findings From the RIETE Registry Chest, May 1, 2005; 127(5): 1631 - 1636. [Abstract] [Full Text] [PDF] A. Falanga and L. Zacharski Deep vein thrombosis in cancer: the scale of the problem and approaches to management Ann. Onc., May 1, 2005; 16(5): 696 - 701. [Abstract] [Full Text] [PDF] S. Schulman and R. J. Beyth Risk of bleeding with long-term antithrombotic therapy in atrial fibrillation Eur. Heart J. Suppl., May 1, 2005; 7(suppl_C): C34 - C40. [Abstract] [Full Text] [PDF] J. A. Batsis and T. I. Morgenthaler Trousseau Syndrome and the Unknown Cancer: Use of Positron Emission Tomographic Imaging in a Patient With a Paraneoplastic Syndrome Mayo Clin. Proc., April 1, 2005; 80(4): 537 - 540. [Abstract] [PDF] J.-N. Fiessinger, M. V. Huisman, B. L. Davidson, H. Bounameaux, C. W. Francis, H. Eriksson, T. Lundstrom, S. D. Berkowitz, P. Nystrom, M. Thorsen, et al. Ximelagatran vs Low-Molecular-Weight Heparin and Warfarin for the Treatment of Deep Vein Thrombosis: A Randomized Trial JAMA, February 9, 2005; 293(6): 681 - 689. [Abstract] [Full Text] [PDF] L. R. Zacharski, P. Prandoni, and M. Monreal Warfarin Versus Low-Molecular-Weight Heparin Therapy in Cancer Patients Oncologist, January 1, 2005; 10(1): 72 - 79. [Abstract] [Full Text] [PDF] S. Sallah, A. Husain, V. Sigounas, J. Wan, F. Turturro, G. Sigounas, and N. P. Nguyen Plasma Coagulation Markers in Patients with Solid Tumors and Venous Thromboembolic Disease Receiving Oral Anticoagulation Therapy Clin. Cancer Res., November 1, 2004; 10(21): 7238 - 7243. [Abstract] [Full Text] [PDF] M. N. Levine, G. Raskob, R. J. Beyth, C. Kearon, and S. Schulman Hemorrhagic Complications of Anticoagulant Treatment: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 287S - 310S. [Abstract] [Full Text] [PDF] W. H. Geerts, G. F. Pineo, J. A. Heit, D. Bergqvist, M. R. Lassen, C. W. Colwell, and J. G. Ray Prevention of Venous Thromboembolism: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 338S - 400S. [Abstract] [Full Text] [PDF] C. Kearon Long-Term Management of Patients After Venous Thromboembolism Circulation, August 31, 2004; 110(9_suppl_1): I-10 - I-18. [Abstract] [Full Text] [PDF] L. S. Elting, C. P. Escalante, C. Cooksley, E. B. C. Avritscher, D. Kurtin, L. Hamblin, S. G. Khosla, and E. Rivera Outcomes and Cost of Deep Venous Thrombosis Among Patients With Cancer Arch Intern Med, August 9, 2004; 164(15): 1653 - 1661. [Abstract] [Full Text] [PDF] B. H. Tonnessen and S. R. Money Low-Molecular-Weight Heparin Versus Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients With Cancer Perspectives in Vascular Surgery and Endovascular Therapy, June 1, 2004; 16(2): 144 - 146. [Abstract] [PDF] V. Pengo, A. W.A. Lensing, M. H. Prins, A. Marchiori, B. L. Davidson, F. Tiozzo, P. Albanese, A. Biasiolo, C. Pegoraro, S. Iliceto, et al. Incidence of Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism N. Engl. J. Med., May 27, 2004; 350(22): 2257 - 2264. [Abstract] [Full Text] [PDF] Writing Committee for the Galilei Investigators Subcutaneous Adjusted-Dose Unfractionated Heparin vs Fixed-Dose Low-Molecular-Weight Heparin in the Initial Treatment of Venous Thromboembolism Arch Intern Med, May 24, 2004; 164(10): 1077 - 1083. [Abstract] [Full Text] [PDF] J. A. Lopez, C. Kearon, and A. Y.Y. Lee Deep Venous Thrombosis Hematology, January 1, 2004; 2004(1): 439 - 456. [Abstract] [Full Text] [PDF] M. V. Huisman, F. J.M. van der Meer, C. J. van Rooden, V. Malik, Y. Kupfer, S. Tessler, H. A. Tran, D. J. Brotman, P. M. Ridker, S. Z. Goldhaber, et al. Low-Intensity versus Conventional-Intensity Warfarin for Prevention of Recurrent Venous Thromboembolism N. Engl. J. Med., November 27, 2003; 349(22): 2164 - 2167. [Full Text] [PDF] E. Blot, F. Gutman, A. Thannberger, J. H.K. Hull, P. J. Hull, J. L. Kaufman, F. Nader, A. Y.Y. Lee, M. N. Levine, M. Gent, et al. Dalteparin Compared with an Oral Anticoagulant for Thromboprophylaxis in Patients with Cancer N. Engl. J. Med., October 2, 2003; 349(14): 1385 - 1387. [Full Text] [PDF] A. Y.Y. Lee, M. N. Levine, R. I. Baker, C. Bowden, A. K. Kakkar, M. Prins, F. R. Rickles, J. A. Julian, S. Haley, M. J. Kovacs, et al. Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer N. Engl. J. Med., July 10, 2003; 349(2): 146 - 153. [Abstract] [Full Text] [PDF] A. Y.Y. Lee and M. N. Levine Venous Thromboembolism and Cancer: Risks and Outcomes Circulation, June 17, 2003; 107(90231): I-17 - 21. [Abstract] [Full Text] [PDF] C. Kearon Natural History of Venous Thromboembolism Circulation, June 17, 2003; 107(90231): I-22 - 30. [Abstract] [Full Text] [PDF] A. I. Schafer, M. N. Levine, B. A. Konkle, and C. Kearon Thrombotic Disorders: Diagnosis and Treatment Hematology, January 1, 2003; 2003(1): 520 - 539. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020