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Prepublished online as a Blood First Edition Paper on July 5, 2002; DOI 10.1182/blood-2002-03-0733.
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Blood, 15 November 2002, Vol. 100, No. 10, pp. 3504-3511
HEMATOPOIESIS
B-cell development in the thymus is limited by
inhibitory signals from the thymic microenvironment
Yoshiko Hashimoto,
Encarnacion Montecino-Rodriguez,
Hyosuk Leathers,
Robert P. Stephan, and
Kenneth Dorshkind
From the Department of Pathology and Laboratory
Medicine and the Jonsson Comprehensive Cancer Center, University of
California at Los Angeles School of Medicine; and the Department of
Developmental and Clinical Immunology, University of Alabama,
Birmingham.
B-cell precursors are present in the thymus, and the thymic
microenvironment is the source of lymphopoietic factors that include interleukin-7 (IL-7). Despite the fact that intrathymic B-cell progenitors are bone marrow-derived cells, the data in this report demonstrate that these progenitors accumulate at an early pro-B-cell stage of development, cycle less than their bone marrow counterparts, and fail to differentiate efficiently. Additional studies presented herein indicate that these effects are mediated, at least in part, by
soluble factors produced by the thymic microenvironment and suggest
that they affect the ability of pro-B cells to respond optimally to
IL-7. Taken together, these observations demonstrate a specific
inhibition of intrathymic B lymphopoiesis, which in turn may explain
why lymphoid cell production in the thymus is largely restricted to
production of T-lineage cells despite the fact that B-cell precursors
and B-lymphopoietic stimuli are present in that organ.
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