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Prepublished online as a Blood First Edition Paper on July 5, 2002; DOI 10.1182/blood-2002-01-0312. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-01-0312v1 100/10/3646    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cremer, I. Articles by Mueller, C. G. F. Search for Related Content PubMed PubMed Citation Articles by Cremer, I. Articles by Mueller, C. G. F. Related Collections Hematopoiesis and Stem Cells Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 November 2002, Vol. 100, No. 10, pp. 3646-3655 IMMUNOBIOLOGY Long-lived immature dendritic cells mediated by TRANCE-RANK interaction Isabelle Cremer, Marie-Caroline Dieu-Nosjean, Sylvie Maréchal, Colette Dezutter-Dambuyant, Sarah Goddard, David Adams, Nathalie Winter, Christine Menetrier-Caux, Catherine Sautès-Fridman, Wolf H. Fridman, and Chris G. F. Mueller From the Institut National de la Santé et de la Recherche Médicale (INSERM) U255, Centre de Recherches Biomédicales des Cordeliers, and Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France; INSERM U346, Hôpital Edouard Herriot, and INSERM U453, Centre Léon Bérard, Lyon, France; and Liver Unit Laboratories, Queen Elizabeth Hospital, Birmingham, Great Britain. Immature dendritic cells (DCs) reside in interstitial tissues (int-DC) or in the epidermis, where they capture antigen and, thereafter, mature and migrate to draining lymph nodes (LNs), where they present processed antigen to T cells. We have identified int-DCs that express both TRANCE (tumor necrosis factor-related activation-induced cytokine) and RANK (receptor activator of NF-B) and have generated these cells from CD34+ human progenitor cells using macrophage colony-stimulating factor (M-CSF). These CD34+-derived int-DCs, which are related to macrophages, are long-lived, but addition of soluble RANK leads to significant reduction of cell viability and Bcl-2 expression. This suggests that constitutive TRANCE-RANK interaction is responsible for CD34+-derived int-DC longevity. Conversely, CD1a+ DCs express only RANK and are short-lived. However, they can be rescued from cell death either by recombinant soluble TRANCE or by CD34+-derived int-DCs. CD34+-derived int-DCs mature in response to lipopolysaccharide (LPS) plus CD40 ligand (L) and become capable of CCL21/CCL19-mediated chemotaxis and naive T-cell activation. Upon maturation, they lose TRANCE, making them, like CD1a+ DCs, dependent on exogenous TRANCE for survival. These findings provide evidence that TRANCE and RANK play important roles in the homeostasis of DCs. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Chino, K. E. Draves, and E. A. Clark Regulation of dendritic cell survival and cytokine production by osteoprotegerin J. Leukoc. Biol., October 1, 2009; 86(4): 933 - 940. [Abstract] [Full Text] [PDF] S. Kwan Tat, N. Amiable, J.-P. Pelletier, C. Boileau, D. Lajeunesse, N. Duval, and J. 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