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Prepublished online as a Blood First Edition Paper on July 5, 2002; DOI 10.1182/blood-2002-04-1197. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1197v1 100/10/3825    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Davies, S. M. Articles by Blazar, B. R. Search for Related Content PubMed PubMed Citation Articles by Davies, S. M. Articles by Blazar, B. R. Related Collections Immunobiology Transplantation Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 November 2002, Vol. 100, No. 10, pp. 3825-3827 BRIEF REPORT Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants Stella M. Davies, Loredana Ruggieri, Todd DeFor, John E. Wagner, Daniel J. Weisdorf, Jeffrey S. Miller, Andrea Velardi, and Bruce R. Blazar From the Blood and Marrow Transplant Program, University of Minnesota, Minneapolis; and Department of Clinical and Experimental Medicine, Division of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy. One of the functions of HLA class I alleles is interaction with natural killer (NK) cells. Receptors termed killer immunoglobulinlike receptors (KIRs) on NK cells recognize groups of HLA class I alleles, and interaction between receptor and class I allele inhibits reactivity of the NK cell. Failure to recognize the appropriate KIR ligand on a mismatched cell can trigger NK cell elimination of that target cell. Recent analysis of haploidentical hematopoietic transplantations has shown a reduction of graft failure, graft-versus-host disease, and relapse in those with KIR ligand incompatibility in the graft-versus-host direction. In this study we analyzed the effect of KIR ligand incompatibility on outcomes of unrelated donor bone marrow transplantations. The data show no advantage for KIR ligand incompatibility in this clinical setting as assessed by HLA-Bw4 and HLA-C alleles. It is possible that there will be a benefit of NK cell alloreactivity if strategies of haploidentical transplantation are used: high stem cell doses, extensive T-cell depletion, and no postgrafting immune suppression. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. G. Brunstein, J. E. Wagner, D. J. Weisdorf, S. Cooley, H. Noreen, J. N. Barker, T. DeFor, M. R. Verneris, B. R. Blazar, and J. S. Miller Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity Blood, May 28, 2009; 113(22): 5628 - 5634. [Abstract] [Full Text] [PDF] H.-J. Kolb Graft-versus-leukemia effects of transplantation and donor lymphocytes Blood, December 1, 2008; 112(12): 4371 - 4383. [Abstract] [Full Text] [PDF] C. Fauriat, S. Andersson, A. T. Bjorklund, M. Carlsten, M. Schaffer, N. K. Bjorkstrom, B. C. 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