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Prepublished online as a Blood First Edition Paper on August 1, 2002; DOI 10.1182/blood-2002-02-0602.
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Blood, 1 December 2002, Vol. 100, No. 12, pp. 3861-3868
CHEMOKINES
Marked increase in CC chemokine gene expression in both human and
mouse mast cell transcriptomes following Fc receptor I
cross-linking: an interspecies comparison
Toshiharu Nakajima,
Naoki Inagaki,
Hiroyuki Tanaka,
Akane Tanaka,
Mamoru Yoshikawa,
Mayumi Tamari,
Koichi Hasegawa,
Kenji Matsumoto,
Hiroshi Tachimoto,
Motohiro Ebisawa,
Gozoh Tsujimoto,
Hiroshi Matsuda,
Hiroichi Nagai, and
Hirohisa Saito
From the Department of Allergy and Immunology and
Department of Molecular Pharmacology, National Research Institute for
Child Health and Development, Tokyo, Japan; Department of
Pharmacology, Gifu Pharmaceutical University, Gifu, Japan;
Department of Veterinary Clinic, Faculty of Agriculture, Tokyo
University of Agriculture and Technology, Tokyo, Japan;
Research Team for Allergy Transcriptome, RIKEN Research Center for
Allergy and Immunology, Yokohama, Japan; Laboratory for
Functional Analysis, RIKEN SNP Research Center, Yokohama,
Japan; Department of Pediatrics, National Sagamihara
Hospital, Sagamihara, Japan.
Rodent mast cells (MCs) are common experimental tools but are
somewhat different from their human counterparts in their responses to
certain cytokines and drugs. We examined the expression of more than
10 000 distinct genes in human and mouse cultured MCs using
high-density oligonucleotide probe arrays to find molecules similarly
regulated and expressed by the 2 MC types. After stimulation via
high-affinity Fc receptor I (FcRI), the transcriptional levels of
several CC chemokines were markedly increased, and I-309 (CCL1),
macrophage inflammatory protein-1 (MIP-1) (CCL3) and MIP-1
(CCL4) were found among the 10 most increased human and mouse
transcripts from approximately 12 000 genes (including some expressed
sequence tags). In addition, a costimulatory molecule that was
originally found on the membrane of activated T cells, 4-1BB (CD137),
was found among the 10 most increased transcripts. The FcRI-induced
expression of CC chemokines and 4-1BB was also detected at the protein
level in both MC types. The conservation of these responses suggests
that MCs play a crucial role in recruitment of various CCR-expressing
cells into the tissue in a manner dependent on immunoglobin E,
and that FcRI-mediated induction of several CC chemokines and
4-1BB is highly conserved between human and mouse. Interspecies
comparison studies at the whole genome expression level should be
useful for the interpretation of experimental data obtained in animal
models of human pathobiology.
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