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Prepublished online as a Blood First Edition Paper on July 18, 2002; DOI 10.1182/blood-2002-03-0809. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-03-0809v1 100/12/4074    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de Andrés, B. Articles by Gaspar, M. L. Search for Related Content PubMed PubMed Citation Articles by de Andrés, B. Articles by Gaspar, M. L. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 December 2002, Vol. 100, No. 12, pp. 4074-4081 IMMUNOBIOLOGY The first 3 days of B-cell development in the mouse embryo Belén de Andrés, Pilar Gonzalo, Susana Minguet, José A. Martínez-Marín, Pilar G. Soro, Miguel Angel R. Marcos, and María Luisa Gaspar From Centro Nacional de Microbiología, Instituto de Salud Carlos III (ISCIII), Majadahonda, Spain; and the Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain. B-lineage-committed cells are believed to arise in the liver of mouse embryos at 14 days after coitus (dpc). However, pre-B-specific gene transcripts and DJH gene rearrangements have been detected in earlier, midgestation embryos. We describe here a population of c-kit+AA4.1+CD19+Pax5+ cells present in the aorta-gonad-mesonephros (AGM) area and in the livers of 11-dpc mouse embryos. In contrast to multipotent c-kit+AA4.1+CD19 hematopoietic stem cells (HSCs), these c-kit+AA4.1+CD19+ progenitors differentiated only to B-lineage cells in vitro. We propose that mouse embryonic B lymphopoiesis starts earlier than previously thought, at 10 to 11 dpc, both in liver and extra-liver hematopoietic sites. The B-cell differentiation program is not delayed with respect to the emerging lymphohematopoiesis events in the midgestation mouse embryo (8-9 dpc). © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. L. Esplin, R. S. Welner, Q. Zhang, L. A. Borghesi, and P. W. Kincade A differentiation pathway for B1 cells in adult bone marrow PNAS, April 7, 2009; 106(14): 5773 - 5778. [Abstract] [Full Text] [PDF] B. Gozalbo-Lopez, P. Andrade, G. Terrados, B. de Andres, N. Serrano, I. Cortegano, B. Palacios, A. Bernad, L. Blanco, M. A. R. Marcos, et al. A Role for DNA Polymerase {micro} in the Emerging DJH Rearrangements of the Postgastrulation Mouse Embryo Mol. Cell. Biol., March 1, 2009; 29(5): 1266 - 1275. [Abstract] [Full Text] [PDF] B. de Andres, I. Cortegano, N. Serrano, B. del Rio, P. Martin, P. Gonzalo, M. A. R. Marcos, and M. L. Gaspar A Population of CD19highCD45R /lowCD21low B Lymphocytes Poised for Spontaneous Secretion of IgG and IgA Antibodies J. Immunol., October 15, 2007; 179(8): 5326 - 5334. [Abstract] [Full Text] [PDF] T. Yokota, J. Huang, M. Tavian, Y. Nagai, J. Hirose, J.-C. Zuniga-Pflucker, B. Peault, and P. W. Kincade Tracing the first waves of lymphopoiesis in mice Development, May 15, 2006; 133(10): 2041 - 2051. [Abstract] [Full Text] [PDF] R. Haddad, P. Guardiola, B. Izac, C. Thibault, J. Radich, A.-L. Delezoide, C. Baillou, F. M. Lemoine, J. C. Gluckman, F. Pflumio, et al. Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood Blood, December 15, 2004; 104(13): 3918 - 3926. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020