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Prepublished online as a Blood First Edition Paper on August 22, 2002; DOI 10.1182/blood-2002-05-1299. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-05-1299v1 100/13/4259    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Choi, E. Y. Articles by Roopenian, D. C. Search for Related Content PubMed PubMed Citation Articles by Choi, E. Y. Articles by Roopenian, D. C. Related Collections Transplantation Plenary Papers Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 December 2002, Vol. 100, No. 13, pp. 4259-4264 PLENARY PAPER Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease Eun Young Choi, Gregory J. Christianson, Yoshitaka Yoshimura, Nadja Jung, Thomas J. Sproule, Subramaniam Malarkannan, Sebastian Joyce, and Derry C. Roopenian From the Jackson Laboratory, Bar Harbor, ME; Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN; and Department of Medicine, Blood Research Institute, Milwaukee, WI. Although CD8 T cells are thought to be a principal effector population of graft-versus-host disease (GVHD), their dynamics and specificity remain a mystery. Using a mouse model in which donor and recipient were incompatible at many minor histocompatibility antigens (minor H Ags), the CD8 T-cell response was tracked temporally and spatially through the course of GVHD. Donor CD8 T cells in the circulation, spleen, lung, and liver demonstrated virtually identical kinetics: rapid expansion and then decline prior to morbidity. Remarkably, up to one fourth of the CD8 T cells were directed against a single minor antigen, H60. Extreme H60 immunodominance occurred regardless of sampling time, site, and genetic background. This study is the first to analyze the T cells participating in GVHD in "real-time," demonstrates the exceptional degree to which immunodominance of H60 can occur, and suggests that such superdominant minor H Ags could be risk factors for GVHD. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. 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