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Prepublished online as a Blood First Edition Paper on August 22, 2002; DOI 10.1182/blood-2002-04-1246. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1246v1 2002-04-1246v2 100/13/4266    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Quesenberry, P. J. Articles by Lambert, J.-F. Search for Related Content PubMed PubMed Citation Articles by Quesenberry, P. J. Articles by Lambert, J.-F. Related Collections Perspectives Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 December 2002, Vol. 100, No. 13, pp. 4266-4271 PERSPECTIVE The chiaroscuro stem cell: a unified stem cell theory Peter J. Quesenberry, Gerald A. Colvin, and Jean-Francois Lambert From the Roger Williams Medical Center, Providence, RI. Hematopoiesis has been considered hierarchical in nature, but recent data suggest that the system is not hierarchical and is, in fact, quite functionally plastic. Existing data indicate that engraftment and progenitor phenotypes vary inversely with cell cycle transit and that gene expression also varies widely. These observations suggest that there is no progenitor/stem cell hierarchy, but rather a reversible continuum. This may, in turn, be dependent on shifting chromatin and gene expression with cell cycle transit. If the phenotype of these primitive marrow cells changes from engraftable stem cell to progenitor and back to engraftable stem cell with cycle transit, then this suggests that the identity of the engraftable stem cell may be partially masked in nonsynchronized marrow cell populations. A general model indicates a marrow cell that can continually change its surface receptor expression and thus responds to external stimuli differently at different points in the cell cycle. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Ono, T. Maruyama, H. Masuda, T. Kajitani, T. Nagashima, T. Arase, M. Ito, K. Ohta, H. Uchida, H. Asada, et al. Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells PNAS, November 20, 2007; 104(47): 18700 - 18705. [Abstract] [Full Text] [PDF] D. 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