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Prepublished online as a Blood First Edition Paper on August 22, 2002; DOI 10.1182/blood-2002-04-1246.
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Blood, 15 December 2002, Vol. 100, No. 13, pp. 4266-4271
PERSPECTIVE
The chiaroscuro stem cell: a unified stem cell theory
Peter J. Quesenberry,
Gerald A. Colvin, and
Jean-Francois Lambert
From the Roger Williams Medical Center, Providence, RI.
Hematopoiesis has been considered hierarchical in nature,
but recent data suggest that the system is not hierarchical and is, in
fact, quite functionally plastic. Existing data indicate that
engraftment and progenitor phenotypes vary inversely with cell cycle
transit and that gene expression also varies widely. These observations
suggest that there is no progenitor/stem cell hierarchy, but rather a
reversible continuum. This may, in turn, be dependent on shifting
chromatin and gene expression with cell cycle transit. If the phenotype
of these primitive marrow cells changes from engraftable stem cell to
progenitor and back to engraftable stem cell with cycle transit, then
this suggests that the identity of the engraftable stem cell may be
partially masked in nonsynchronized marrow cell populations. A general
model indicates a marrow cell that can continually change its surface
receptor expression and thus responds to external stimuli differently
at different points in the cell cycle.
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