|
|
Prepublished online as a Blood First Edition Paper on August 8, 2002; DOI 10.1182/blood-2002-06-1778.
 Previous Article | Table of Contents | Next Article 
Blood, 15 December 2002, Vol. 100, No. 13, pp. 4446-4453
HEMATOPOIESIS
Specific involvement of caspases in the differentiation of
monocytes into macrophages
Olivier Sordet,
Cédric Rébé,
Stéphanie Plenchette,
Yaël Zermati,
Olivier Hermine,
William Vainchenker,
Carmen Garrido,
Eric Solary, and
Laurence Dubrez-Daloz
From Institut National de la Santé et de la
Recherche Médicale (INSERM) U517, Institut Fédératif
de Recherche (IFR) 100, Faculty of Medicine, Dijon, France; Centre
National de Recherches Scientifiques (CNRS) UMR 8603, IFR Necker,
Paris, France; and INSERM U362, Institut Gustave Roussy,
Villejuif, France.
Caspases are cysteine proteases involved in apoptosis and cytokine
maturation. In erythroblasts, keratinocytes, and lens epithelial cells
undergoing differentiation, enucleation has been regarded as a
caspase-mediated incomplete apoptotic process. Here, we show that
several caspases are activated in human peripheral blood monocytes
whose differentiation into macrophages is induced by macrophage colony-stimulating factor (M-CSF). This
activation is not associated with cell death and cannot be detected in
monocytes undergoing dendritic cell differentiation in the presence of
interleukin-4 (IL-4) and granulocyte-macrophage
colony-stimulating factor (GM-CSF). The mechanisms and
consequences of caspase activation were further studied in U937 human
monocytic cells undergoing phorbol ester-induced differentiation
into macrophages. Differentiation-associated caspase activation
involves the release of cytochrome c from the mitochondria and leads to
the cleavage of the protein acinus while the poly(ADP-ribose)polymerase remains uncleaved. Inhibition of caspases by either exposure to the
broad-spectrum inhibitor
benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone (z-VAD-fmk) or expression of the p35 baculovirus inhibitory protein or
overexpression of Bcl-2 inhibits the differentiation process. In
addition, z-VAD-fmk amplifies the differentiation-associated production
of radical oxygen species in both phorbol ester-differentiated U937 cells and M-CSF-treated monocytes, shifting the
differentiation process to nonapoptotic cell death. Altogether, these
results indicate that caspase activation specifically contributes to
the differentiation of monocytes into macrophages, in the absence of
cell death.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. L. Scott, G. J. Fuchs, S. E. Boyd, J.-B. Denault, C. J. Hawkins, F. Dequiedt, and G. S. Salvesen
Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function
J. Biol. Chem.,
July 11, 2008;
283(28):
19499 - 19510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-A. T. Tan, Y. Sun, J. Song, Y. Chen, T. G. Krontiris, and L. K. Durrin
SUMO Conjugation to the Matrix Attachment Region-binding Protein, Special AT-rich Sequence-binding Protein-1 (SATB1), Targets SATB1 to Promyelocytic Nuclear Bodies Where It Undergoes Caspase Cleavage
J. Biol. Chem.,
June 27, 2008;
283(26):
18124 - 18134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Netea, E. C. Lewis, T. Azam, L. A. B. Joosten, J. Jaekal, S.-Y. Bae, C. A. Dinarello, and S.-H. Kim
Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
PNAS,
March 4, 2008;
105(9):
3515 - 3520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Lakshmanan and A. G. Porter
Caspase-4 Interacts with TNF Receptor-Associated Factor 6 and Mediates Lipopolysaccharide-Induced NF-{kappa}B-Dependent Production of IL-8 and CC Chemokine Ligand 4 (Macrophage-Inflammatory Protein-1 )
J. Immunol.,
December 15, 2007;
179(12):
8480 - 8490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Lo, P. Gorak-Stolinska, V. Bachy, M. A. Ibrahim, D. M. Kemeny, and J. Maher
Modulation of dendritic cell differentiation by colony-stimulating factor-1: role of phosphatidylinositol 3'-kinase and delayed caspase activation
J. Leukoc. Biol.,
December 1, 2007;
82(6):
1446 - 1454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Truscott, J.-B. Denault, B. Goulet, L. Leduy, G. S. Salvesen, and A. Nepveu
Carboxyl-terminal Proteolytic Processing of CUX1 by a Caspase Enables Transcriptional Activation in Proliferating Cells
J. Biol. Chem.,
October 12, 2007;
282(41):
30216 - 30226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Misra, J. Q. Russell, A. Koenig, J. A. Hinshaw-Makepeace, R. Wen, D. Wang, H. Huo, D. R. Littman, U. Ferch, J. Ruland, et al.
Caspase-8 and c-FLIPL Associate in Lipid Rafts with NF-{kappa}B Adaptors during T Cell Activation
J. Biol. Chem.,
July 6, 2007;
282(27):
19365 - 19374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Drouineaud, P. Sagot, C. Garrido, E. Logette, V. Deckert, P. Gambert, C. Jimenez, B. Staels, L. Lagrost, and D. Masson
Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists
Mol. Hum. Reprod.,
June 1, 2007;
13(6):
373 - 379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Lasbury, S. Merali, P. J. Durant, D. Tschang, C. A. Ray, and C.-H. Lee
Polyamine-mediated Apoptosis of Alveolar Macrophages during Pneumocystis Pneumonia
J. Biol. Chem.,
April 13, 2007;
282(15):
11009 - 11020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Samuel, J. D. Morrey, and M. S. Diamond
Caspase 3-Dependent Cell Death of Neurons Contributes to the Pathogenesis of West Nile Virus Encephalitis
J. Virol.,
March 15, 2007;
81(6):
2614 - 2623.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Rebe, S. Cathelin, S. Launay, R. Filomenko, L. Prevotat, C. L'Ollivier, E. Gyan, O. Micheau, S. Grant, A. Dubart-Kupperschmitt, et al.
Caspase-8 prevents sustained activation of NF-{kappa}B in monocytes undergoing macrophagic differentiation
Blood,
February 15, 2007;
109(4):
1442 - 1450.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Rautajoki, E. M. Marttila, T. A. Nyman, and R. Lahesmaa
Interleukin-4 Inhibits Caspase-3 by Regulating Several Proteins in the Fas Pathway during Initial Stages of Human T Helper 2 Cell Differentiation
Mol. Cell. Proteomics,
February 1, 2007;
6(2):
238 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. I Arroba, A. M Lechuga-Sancho, L. M Frago, J. Argente, and J. A Chowen
Cell-specific expression of X-linked inhibitor of apoptosis in the anterior pituitary of streptozotocin-induced diabetic rats
J. Endocrinol.,
January 1, 2007;
192(1):
215 - 227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Fernando and L. A. Megeney
Is caspase-dependent apoptosis only cell differentiation taken to the extreme?
FASEB J,
January 1, 2007;
21(1):
8 - 17.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Sordet, A. Goldman, and Y. Pommier
Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes
Mol. Cancer Ther.,
December 1, 2006;
5(12):
3139 - 3144.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Hars, Y. L. Lyu, C.-P. Lin, and L. F. Liu
Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia.
Cancer Res.,
September 15, 2006;
66(18):
8975 - 8979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Muller, J. Grunewald, C. Olgart Hoglund, B. Dahlen, A. Eklund, and H. Stridh
Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects
Eur. Respir. J.,
September 1, 2006;
28(3):
513 - 522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Q. Nhan, W. C. Liles, and S. M. Schwartz
Physiological Functions of Caspases Beyond Cell Death
Am. J. Pathol.,
September 1, 2006;
169(3):
729 - 737.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Xu, S. O. Kim, Y. Li, and J. Han
Autophagy Contributes to Caspase-independent Macrophage Cell Death
J. Biol. Chem.,
July 14, 2006;
281(28):
19179 - 19187.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Darnowski, F. A. Goulette, Y.-j. Guan, D. Chatterjee, Z.-F. Yang, L. P. Cousens, and Y. E. Chin
Stat3 Cleavage by Caspases: IMPACT ON FULL-LENGTH Stat3 EXPRESSION, FRAGMENT FORMATION, AND TRANSCRIPTIONAL ACTIVITY
J. Biol. Chem.,
June 30, 2006;
281(26):
17707 - 17717.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Cathelin, C. Rebe, L. Haddaoui, N. Simioni, F. Verdier, M. Fontenay, S. Launay, P. Mayeux, and E. Solary
Identification of Proteins Cleaved Downstream of Caspase Activation in Monocytes Undergoing Macrophage Differentiation
J. Biol. Chem.,
June 30, 2006;
281(26):
17779 - 17788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kalamvoki, U. Georgopoulou, and P. Mavromara
The NS5A Protein of the Hepatitis C Virus Genotype 1a Is Cleaved by Caspases to Produce C-terminal-truncated Forms of the Protein That Reside Mainly in the Cytosol
J. Biol. Chem.,
May 12, 2006;
281(19):
13449 - 13462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lemarie, C. Morzadec, D. Merino, O. Micheau, O. Fardel, and L. Vernhet
Arsenic Trioxide Induces Apoptosis of Human Monocytes during Macrophagic Differentiation through Nuclear Factor-{kappa}B-Related Survival Pathway Down-Regulation
J. Pharmacol. Exp. Ther.,
January 1, 2006;
316(1):
304 - 314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Logette, C. Le Jossic-Corcos, D. Masson, S. Solier, A. Sequeira-Legrand, I. Dugail, S. Lemaire-Ewing, L. Desoche, E. Solary, and L. Corcos
Caspase-2, a Novel Lipid Sensor under the Control of Sterol Regulatory Element Binding Protein 2
Mol. Cell. Biol.,
November 1, 2005;
25(21):
9621 - 9631.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. S. Kim and M.-S. Lee
Essential Role of STAT1 in Caspase-Independent Cell Death of Activated Macrophages through the p38 Mitogen-Activated Protein Kinase/STAT1/Reactive Oxygen Species Pathway
Mol. Cell. Biol.,
August 1, 2005;
25(15):
6821 - 6833.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Krajewska, H. Kim, E. Shin, S. Kennedy, M. J. Duffy, Y. F. Wong, D. Marr, J. Mikolajczyk, A. Shabaik, I. Meinhold-Heerlein, et al.
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies
Clin. Cancer Res.,
August 1, 2005;
11(15):
5462 - 5471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. F. Weber and A. S. Menko
The Canonical Intrinsic Mitochondrial Death Pathway Has a Non-apoptotic Role in Signaling Lens Cell Differentiation
J. Biol. Chem.,
June 10, 2005;
280(23):
22135 - 22145.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pederzoli, C. Kantari, V. Gausson, S. Moriceau, and V. Witko-Sarsat
Proteinase-3 Induces Procaspase-3 Activation in the Absence of Apoptosis: Potential Role of this Compartmentalized Activation of Membrane-Associated Procaspase-3 in Neutrophils
J. Immunol.,
May 15, 2005;
174(10):
6381 - 6390.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Q. Nhan, W. C. Liles, and S. M. Schwartz
Role of Caspases in Death and Survival of the Plaque Macrophage
Arterioscler. Thromb. Vasc. Biol.,
May 1, 2005;
25(5):
895 - 903.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Denis, A. Benecke, Y. Di Gioia, I. P. Touw, Y. E. Cayre, and P. G. Lutz
PRAM-1 Potentiates Arsenic Trioxide-induced JNK Activation
J. Biol. Chem.,
March 11, 2005;
280(10):
9043 - 9048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Lang, S. Reuter, T. Buzescu, C. August, and S. Heidenreich
Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation
Int. Immunol.,
February 1, 2005;
17(2):
155 - 165.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Sordet, Q. A. Khan, I. Plo, P. Pourquier, Y. Urasaki, A. Yoshida, S. Antony, G. Kohlhagen, E. Solary, M. Saparbaev, et al.
Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals
J. Biol. Chem.,
November 26, 2004;
279(48):
50499 - 50504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Plenchette, S. Cathelin, C. Rebe, S. Launay, S. Ladoire, O. Sordet, T. Ponnelle, N. Debili, T.-H. Phan, R.-A. Padua, et al.
Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event
Blood,
October 1, 2004;
104(7):
2035 - 2043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-B. Kang, T. Ben-Moshe, E. E. Varfolomeev, Y. Pewzner-Jung, N. Yogev, A. Jurewicz, A. Waisman, O. Brenner, R. Haffner, E. Gustafsson, et al.
Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles
J. Immunol.,
September 1, 2004;
173(5):
2976 - 2984.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Sordet, Z. Liao, H. Liu, S. Antony, E. V. Stevens, G. Kohlhagen, H. Fu, and Y. Pommier
Topoisomerase I-DNA Complexes Contribute to Arsenic Trioxide-induced Apoptosis
J. Biol. Chem.,
August 6, 2004;
279(32):
33968 - 33975.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Skeen, M. M. Freeman, and H. K. Ziegler
Changes in peritoneal myeloid populations and their proinflammatory cytokine expression during infection with Listeria monocytogenes are altered in the absence of {gamma}/{delta} T cells
J. Leukoc. Biol.,
July 1, 2004;
76(1):
104 - 115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Schmitt, A. Parcellier, F. Ghiringhelli, N. Casares, S. Gurbuxani, N. Droin, A. Hamai, M. Pequignot, A. Hammann, M. Moutet, et al.
Increased Immunogenicity of Colon Cancer Cells by Selective Depletion of Cytochrome c
Cancer Res.,
April 15, 2004;
64(8):
2705 - 2711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Yacobi, A. Wojtowicz, A. Tsafriri, and A. Gross
Gonadotropins Enhance Caspase-3 and -7 Activity and Apoptosis in the Theca-Interstitial Cells of Rat Preovulatory Follicles in Culture
Endocrinology,
April 1, 2004;
145(4):
1943 - 1951.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. K. Callahan, M. S. Halleck, S. Krahling, A. J. Henderson, P. Williamson, and R. A. Schlegel
Phosphatidylserine expression and phagocytosis of apoptotic thymocytes during differentiation of monocytic cells
J. Leukoc. Biol.,
November 1, 2003;
74(5):
846 - 856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Park, A. R. Thomsen, C. W. Frevert, U. Pham, S. J. Skerrett, P. A. Kiener, and W. C. Liles
Fas (CD95) Induces Proinflammatory Cytokine Responses by Human Monocytes and Monocyte-Derived Macrophages
J. Immunol.,
June 15, 2003;
170(12):
6209 - 6216.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
