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Blood, 15 July 2002, Vol. 100, No. 2, pp. 698-700
BRIEF REPORT
Absence of biologically important Kaposi sarcoma-associated
herpesvirus gene products and virus-specific cellular immune responses
in multiple myeloma
Christian Brander,
Noopur Raje,
Paula G. O'Connor,
Faith Davies,
Jennifer Davis,
Darminder Chauhan,
Teru Hideshima,
Jeff Martin,
Dennis Osmond,
Dean H. Kedes,
Bruce D. Walker,
David T. Scadden, and
Kenneth C. Anderson
From Partners AIDS Research Center, Massachusetts
General Hospital, Charlestown, and the Department of Adult Oncology,
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA; the
Department of Epidemiology and Biostatistics, University of California,
San Francisco; and the Departments of Microbiology and Medicine, Myles
H. Thaler Center for AIDS Research, University of Virginia Health
Systems, Charlottesville.
Kaposi sarcoma-associated herpesvirus (KSHV) has been associated
with several diseases, but the association between KSHV and multiple
myeloma (MM) remains controversial. To address this issue, we studied
patients with MM for the presence of viral RNA transcripts as well as
KSHV-specific cellular immune responses. Highly sensitive reverse
transcription-polymerase chain reaction assays for detection of viral
transcripts of KSHV open reading frame (ORF) 26, ORF72, and ORF74 did
not detect viral gene transcripts in long-term cultures of bone marrow
stromal cells from 23 patients with MM. Moreover, sensitive assays for
KSHV ORF65-specific and ORF73-specific cytotoxic T-lymphocyte (CTL)
activity that readily and routinely detect CTLs specific for ORF65 and
ORF73 in patients positive for human immunodeficiency virus and KSHV
did not show any specific responses in 16 patients with MM, despite the
presence of positive Epstein-Barr virus-specific CTLs in all cases.
These data therefore do not show a biologically important association
between ongoing KSHV infection and MM.
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