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Prepublished online as a Blood First Edition Paper on May 24, 2002; DOI 10.1182/blood-2002-01-0149. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-01-0149v1 100/3/1060    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pabinger, I. Articles by Kaider, A. Search for Related Content PubMed PubMed Citation Articles by Pabinger, I. Articles by Kaider, A. Related Collections Brief Reports Clinical Trials and Observations Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2002, Vol. 100, No. 3, pp. 1060-1062 BRIEF REPORT Temporary increase in the risk for recurrence during pregnancy in women with a history of venous thromboembolism Ingrid Pabinger, Helga Grafenhofer, Paul A. Kyrle, Peter Quehenberger, Christine Mannhalter, Klaus Lechner, and Alexandra Kaider From the Department of Internal Medicine I, Division of Haematology and Blood Coagulation, the Department of Laboratory Medicine, and the Department of Medical Computer Sciences, Vienna University Hospital, Austria. There is strong evidence that the incidence of venous thromboembolism (VTE) is increased during pregnancy. However, it is unknown whether and to which extent pregnancy influences the risk for recurrent VTE in women with previous thrombosis. To investigate whether pregnancy temporarily increases the risk for recurrent thrombosis, we retrospectively evaluated the recurrence rate in 109 women who had at least one pregnancy after an episode of VTE by comparing the time period during pregnancy with the nonpregnant period. Forty-three women had a first recurrence during a total observation time of 1014 years. Eight events (73 observation years) occurred during pregnancy, and 35 events (941 observation years) occurred outside pregnancy. Recurrence rates per 100 patient-years were 10.9% during and 3.7% outside pregnancy. Relative risk during pregnancy was 3.5 (95% confidence interval, 1.6-7.8; P = .002). Our data suggest that pregnancy leads to a temporary increase in the risk for recurrent thrombotic events. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. M. Bates, I. A. Greer, I. Pabinger, S. Sofaer, and J. Hirsh Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 844S - 886S. [Abstract] [Full Text] [PDF] S. M. Bates Management of Pregnant Women with Thrombophilia or a History of Venous Thromboembolism Hematology, January 1, 2007; 2007(1): 143 - 150. [Abstract] [Full Text] [PDF]

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