SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on April 17, 2002; DOI 10.1182/blood-2001-11-0093. This Article Full Text Full Text (PDF) All Versions of this Article: 2001-11-0093v1 100/3/991    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ballerini, P. Articles by Bernard, O. A. Search for Related Content PubMed PubMed Citation Articles by Ballerini, P. Articles by Bernard, O. A. Related Collections Neoplasia Chemokines, Cytokines, and Interleukins Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2002, Vol. 100, No. 3, pp. 991-997 NEOPLASIA HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis Paola Ballerini, Annick Blaise, Maryvonne Busson-Le Coniat, Xin Ying Su, Jessica Zucman-Rossi, Mircea Adam, Jacqueline van den Akker, Christine Perot, Beatrice Pellegrino, Judith Landman-Parker, Luc Douay, Roland Berger, and Olivier A. Bernard From the Service d'Hématologie Biologique, Hôpital Armand Trousseau, Paris; U434 INSERM-CEPH and SD401 No. 434 CNRS, Paris; UPRES A1638 Université Paris VI; Service de Cytogénétique, Hôpital Saint Antoine, Paris; and EMI0210, Faculté Necker-Enfant Malades, Paris, France. The most frequent oncogenic activation events characterized in childhood T acute lymphoblastic leukemia (T-ALL) result in the transcriptional activation of genes coding for transcription factors. The main genes are TAL1/SCL, a member of the basic region helix-loop-helix gene family, and HOX11L2, a member of the homeobox-containing protein family. To gain insight into the pathogenesis of this type of hematologic malignancy, we analyzed 28 T-ALL samples. SIL-TAL1/SCL fusion was detected in 6 patients; expression of HOX11L2 was observed in 6 patients and of HOX11 in 3 patients. With one exception, these activations did not occur simultaneously in the same patients, and they allowed the subclassification of 50% of the patients. SIL-TAL1 fusion was detected in association with HOX11 expression in one patient and with a t(8;14) (q24;q11) in another. High expression of LYL1, LMO2, or TAL1 was observed mainly in samples negative for HOX11L2 expression. HOX11L1 and HOX11 expression were observed in one instance each, in the absence of detectable chromosomal abnormality of their respective loci, on chromosomes 2 and 10, respectively. HOX11L2 expression was associated with a chromosome 5q abnormality, the location of the HOX11L2 locus in each case tested. Finally, our data show that HOX11L2 expression was a suitable marker for minimal residual disease follow-up and was significantly associated with relapse (P = .02). © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. Su, V. Della-Valle, E. Delabesse, Z. Azgui, R. Berger, H. Merle-Beral, O. A Bernard, and F. Nguyen-Khac Transcriptional activation of the cardiac homeobox gene CSX1/NKX2-5 in a B-cell chronic lymphoproliferative disorder Haematologica, July 1, 2008; 93(7): 1081 - 1085. [Abstract] [Full Text] [PDF] C. D. Baldus, T. Burmeister, P. Martus, S. Schwartz, N. Gokbuget, C. D. Bloomfield, D. Hoelzer, E. Thiel, and W. K. Hofmann High Expression of the ETS Transcription Factor ERG Predicts Adverse Outcome in Acute T-Lymphoblastic Leukemia in Adults J. Clin. Oncol., October 10, 2006; 24(29): 4714 - 4720. [Abstract] [Full Text] [PDF] S. Borghini, M. Vargiolu, M. Di Duca, R. Ravazzolo, and I. Ceccherini Nuclear Factor Y Drives Basal Transcription of the Human TLX3, a Gene Overexpressed in T-Cell Acute Lymphocytic Leukemia Mol. Cancer Res., September 1, 2006; 4(9): 635 - 643. [Abstract] [Full Text] [PDF] Y.-M. Zhu, W.-L. Zhao, J.-F. Fu, J.-Y. Shi, Q. Pan, J. Hu, X.-D. Gao, B. Chen, J.-M. Li, S.-M. Xiong, et al. NOTCH1 Mutations in T-Cell Acute Lymphoblastic Leukemia: Prognostic Significance and Implication in Multifactorial Leukemogenesis. Clin. Cancer Res., May 15, 2006; 12(10): 3043 - 3049. [Abstract] [Full Text] [PDF] V. Asnafi, A. Buzyn, X. Thomas, F. Huguet, N. Vey, J.-M. Boiron, O. Reman, J.-M. Cayuela, V. Lheritier, J.-P. Vernant, et al. Impact of TCR status and genotype on outcome in adult T-cell acute lymphoblastic leukemia: a LALA-94 study Blood, April 15, 2005; 105(8): 3072 - 3078. [Abstract] [Full Text] [PDF] S. Chiaretti, X. Li, R. Gentleman, A. Vitale, M. Vignetti, F. Mandelli, J. Ritz, and R. Foa Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival Blood, April 1, 2004; 103(7): 2771 - 2778. [Abstract] [Full Text] [PDF] S. Nagel, M. Kaufmann, H. G. Drexler, and R. A. F. MacLeod The Cardiac Homeobox Gene NKX2-5 Is Deregulated by Juxtaposition with BCL11B in Pediatric T-ALL Cell Lines via a Novel t(5;14)(q35.1;q32.2) Cancer Res., September 1, 2003; 63(17): 5329 - 5334. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020