Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Prepublished online as a Blood First Edition Paper on April 30, 2002; DOI 10.1182/blood-2001-11-0007.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2001-11-0007v1
100/4/1499    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carreau, M.
Right arrow Articles by Buchwald, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carreau, M.
Right arrow Articles by Buchwald, M.
Related Collections
Right arrow Red Cells
Right arrow Brief Reports
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 15 August 2002, Vol. 100, No. 4, pp. 1499-1501

BRIEF REPORT

Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fanccminus /minus mouse model, while long-term treatment is ineffective

Madeleine Carreau, Lili Liu, Olga I. Gan, Johann K. Hitzler, John E. Dick, and Manuel Buchwald

From the Unité de génétique humaine et moléculaire, CHUQ-Hôpital St-François d'Assise, Québec, QC, Canada; the Department of Pediatrics, Laval University, Québec, QC, Canada; the Program in Genetic and Genomic Biology and the Program in Cancer/Blood Research, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; and the Department of Molecular and Medical Genetics and Pediatrics, University of Toronto, Toronto, ON, Canada.

Transient treatment with cytokines appears to improve hematopoietic function in Fanconi anemia; however, the effectiveness or adverse effect of long-term treatment is not known. The mitomycin C-treated Fancc-/- mouse provides a valuable model to address long-term efficacy of such treatment. Fancc-/- mice injected with granulocyte colony-stimulating factor, erythropoietin, or both cytokines showed a delay in mitomycin C (MMC)-induced bone marrow (BM) failure compared to untreated mice. However, long-term cytokine exposure followed by MMC challenges did not protect mice from the reduction of peripheral blood counts or the number of early myeloid progenitors. These results suggest that cytokine treatment may be beneficial only in the short-term, while long-term treatment is not protective for BM aplasia.

© 2002 by The American Society of Hematology.
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Stem CellsHome page
O. Habi, M.-C. Delisle, N. Messier, and M. Carreau
Lack of Self-Renewal Capacity in Fancc-/- Stem Cells After Ex Vivo Expansion
Stem Cells, September 1, 2005; 23(8): 1135 - 1141.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020