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Prepublished online as a Blood First Edition Paper on May 13, 2002; DOI 10.1182/blood-2002-01-0015. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-01-0015v1 100/5/1919    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Deng, H. Articles by Sun, R. Search for Related Content PubMed PubMed Citation Articles by Deng, H. Articles by Sun, R. Related Collections Neoplasia Gene Expression Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2002, Vol. 100, No. 5, pp. 1919-1921 BRIEF REPORT Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression Hongyu Deng, Julia T. Chu, Matthew B. Rettig, Otoniel Martinez-Maza, and Ren Sun From the Department of Molecular and Medical Pharmacology and the Department of Medicine, West Los Angeles Veterans Administration Medical Center; the Department of Obstetrics and Gynecology and the Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, AIDS Institute; Molecular Biology Institute and Dental Research Institute, University of California at Los Angeles. Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus (KSHV) is linked to a number of malignancies thought to be driven by cytokines, including interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, activates the viral lytic cycle leading to the expression of several viral genes implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on cellular genes has not been reported. We present evidence that the human IL-6 (hIL-6) gene is up-regulated by Rta. Rta potently activated (up to 164-fold) the hIL-6 promoter in a dose-dependent manner in a transient transfection reporter system. Rta also induced expression of the endogenous hIL-6 gene, as shown by enzyme-linked immunosorbent assays. Activation of the hIL-6 gene by HHV-8/KSHV supports the role of hIL-6 in the development of these malignancies. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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