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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stevens, C. E. Articles by Rubinstein, P. Search for Related Content PubMed PubMed Citation Articles by Stevens, C. E. Articles by Rubinstein, P. Related Collections Transplantation Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 October 2002, Vol. 100, No. 7, pp. 2662-2664 BRIEF REPORT Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells Cladd E. Stevens, Jessica Gladstone, Patricia E. Taylor, Andromachi Scaradavou, Anna Rita Migliaccio, Jan Visser, N. Ludy Dobrila, Carmelita Carrier, Michael Cabbad, Peter Wernet, Joanne Kurtzberg, and Pablo Rubinstein From the Wolf Szmuness Laboratory of Epidemiology, the F. H. Allen Laboratory of Immunogenetics, and the Laboratory of Hematopoietic Progenitors of the New York Blood Center, New York, NY; the Department of Obstetrics and Gynecology, Brooklyn Hospital Medical Center, Brooklyn, NY; Heinreich Heine University, Dusseldorf, Germany; and Duke University Medical Center, Durham, NC. Placental/umbilical cord blood (PCB) is a source of hematopoietic stem cells for bone marrow reconstitution. Engraftment speed and survival are related to the total nucleated cell (TNC) dose of the graft. This study explored the possible influence on engraftment of nucleated red blood cells (NRBCs) in the graft. Automated hematology analyzers were used to enumerate TNCs. NRBCs were counted by visual examination or by using an automated analyzer. Hematopoietic progenitor cells were enumerated as either colony-forming cells or CD34+ cells. Transplant centers reported on transplant outcome in 1112 patients given PCB grafts through September 2001. NRBCs correlated with progenitor cell numbers. Both white blood cell and NRBC dose were independently predictive of myeloid engraftment speed. Because NRBC dose predicted engraftment speed, inclusion of NRBCs in the TNC count does not reduce the effectiveness of the prefreezing TNC count as an index of the quality of a PCB unit as a graft. The correlation between the number of NRBCs and the number of hematopoietic progenitor cells probably reflects the involvement of early stem cells in erythroid responses. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. S. Grewal, J. N. Barker, S. M. Davies, and J. E. Wagner Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood? Blood, June 1, 2003; 101(11): 4233 - 4244. [Full Text] [PDF]

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