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Prepublished online as a Blood First Edition Paper on June 21, 2002; DOI 10.1182/blood-2002-04-1149. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1149v1 100/8/2692    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bokoch, G. M. Articles by Diebold, B. A. Search for Related Content PubMed PubMed Citation Articles by Bokoch, G. M. Articles by Diebold, B. A. Related Collections Signal Transduction Review Articles Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 October 2002, Vol. 100, No. 8, pp. 2692-2695 REVIEW ARTICLE Current molecular models for NADPH oxidase regulation by Rac GTPase Gary M. Bokoch and Becky A. Diebold From the Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA. Reactive oxygen species (ROS) have been increasingly recognized as important components of cell signaling in addition to their well-established roles in host defense. The formation of ROS in phagocytic and nonphagocytic cells involves membrane-localized and Rac guanosine triphosphatase (GTPase)-regulated reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase(s). We discuss here the current molecular models for Rac GTPase action in the control of the phagocytic leukocyte NADPH oxidase. As a mechanistically detailed example of Rac GTPase signaling, the NADPH oxidase provides a potential paradigm for signaling by Rho family GTPases in general. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Ueyama, T. Kusakabe, S. Karasawa, T. Kawasaki, A. Shimizu, J. Son, T. L. Leto, A. Miyawaki, and N. Saito Sequential Binding of Cytosolic Phox Complex to Phagosomes through Regulated Adaptor Proteins: Evaluation Using the Novel Monomeric Kusabira-Green System and Live Imaging of Phagocytosis J. Immunol., July 1, 2008; 181(1): 629 - 640. [Abstract] [Full Text] [PDF] W. M. Nauseef Biological Roles for the NOX Family NADPH Oxidases J. Biol. Chem., June 20, 2008; 283(25): 16961 - 16965. [Full Text] [PDF] Y.-Y. Kao, D. Gianni, B. Bohl, R. M. Taylor, and G. M. Bokoch Identification of a Conserved Rac-binding Site on NADPH Oxidases Supports a Direct GTPase Regulatory Mechanism J. Biol. 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