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Prepublished online as a Blood First Edition Paper on May 24, 2002; DOI 10.1182/blood-2002-01-0214. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-01-0214v1 100/8/2852    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ferrero, I. Articles by MacDonald, H. R. Search for Related Content PubMed PubMed Citation Articles by Ferrero, I. Articles by MacDonald, H. R. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 October 2002, Vol. 100, No. 8, pp. 2852-2857 IMMUNOBIOLOGY Mouse CD11c+ B220+ Gr1+ plasmacytoid dendritic cells develop independently of the T-cell lineage Isabel Ferrero, Werner Held, Anne Wilson, Fabienne Tacchini-Cottier, Freddy Radtke, and H. Robson MacDonald From the Ludwig Institute for Cancer Research, Lausanne Branch, and the World Health Organization (WHO) Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Switzerland. The developmental origin of dendritic cells (DCs) is controversial. In the mouse CD8+ and CD8 DC subsets are often considered to be of lymphoid and myeloid origin respectively, although evidence on this point is conflicting. Very recently a novel CD11c+ B220+ DC subset has been identified that appears to be the murine counterpart to interferon alpha (IFN)-producing human plasmacytoid DCs (PDCs). We show here that CD11c+ B220+ mouse PDCs, like human PDCs, are present in the thymus and express T lineage markers such as CD8 and CD4. However, the intrathymic development of PDCs can be completely dissociated from immature T lineage cells in mixed chimeras established with bone marrow cells from mice deficient for either Notch-1 or T-cell factor 1, two independent mutations that severely block early T-cell development. Our data indicate that thymic PDCs do not arise from a bipotential T/DC precursor. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Li, J. Park, D. Foss, and I. 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