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Prepublished online as a Blood First Edition Paper on June 14, 2002; DOI 10.1182/blood-2002-04-1044. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1044v1 100/8/2908    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Geijtenbeek, T. B. H. Articles by van Kooyk, Y. Search for Related Content PubMed PubMed Citation Articles by Geijtenbeek, T. B. H. Articles by van Kooyk, Y. Related Collections Immunobiology Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 October 2002, Vol. 100, No. 8, pp. 2908-2916 IMMUNOBIOLOGY Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo Teunis B. H. Geijtenbeek, Peter C. Groot, Martijn A. Nolte, Sandra J. van Vliet, Shanti T. Gangaram-Panday, Gerard C. F. van Duijnhoven, Georg Kraal, Antoon J. M. van Oosterhout, and Yvette van Kooyk From the Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands; Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands; Department of Pharmacology and Pathophysiology, Faculty of Pharmacy, Utrecht University, The Netherlands Antigen-presenting cells are localized in essentially every tissue, where they operate at the interface of innate and acquired immunity by capturing pathogens and presenting pathogen-derived peptides to T cells. C-type lectins are important pathogen recognition receptors and the C-type lectin, dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN), is unique in that, in addition to pathogen capture, it regulates adhesion processes such as DC trafficking and T-cell synapse formation. We have isolated a murine homologue of DC-SIGN that is identical to the previously reported murine homologue mSIGNR1. mSIGNR1 is more closely related to the human DC-SIGN homologue L-SIGN than to DC-SIGN itself because mSIGNR1 is specifically expressed by liver sinusoidal endothelial cells, similar to L-SIGN, and not by DCs. Moreover, mSIGNR1 is also expressed by medullary and subcapsular macrophages in lymph nodes and by marginal zone macrophages (MZMs) in the spleen. Strikingly, these MZMs are in direct contact with the bloodstream and efficiently capture specific polysaccharide antigens present on the surface of encapsulated bacteria. We have investigated the in vivo function of mSIGNR1 on MZMs in spleen. We demonstrate here that mSIGNR1 functions in vivo as a pathogen recognition receptor on MZMs that capture blood-borne antigens, which are rapidly internalized and targeted to lysosomes for processing. Moreover, the antigen capture is completely blocked in vivo by the blocking mSIGNR1-specific antibodies. Thus, mSIGNR1, a murine homologue of DC-SIGN, is important in the defense against pathogens and this study will facilitate further investigations into the in vivo function of DC-SIGN and its homologues. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Tanne, B. Ma, F. Boudou, L. Tailleux, H. Botella, E. Badell, F. Levillain, M. E. Taylor, K. Drickamer, J. Nigou, et al. A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis J. Exp. Med., September 28, 2009; 206(10): 2205 - 2220. [Abstract] [Full Text] [PDF] V. Srivastava, M. Manchanda, S. Gupta, R. Singla, D. Behera, G. Das, and K. 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