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Prepublished online as a Blood First Edition Paper on June 7, 2002; DOI 10.1182/blood-2002-02-0654. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-02-0654v1 100/8/3037    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Juszczynski, P. Articles by Warzocha, K. Search for Related Content PubMed PubMed Citation Articles by Juszczynski, P. Articles by Warzocha, K. Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 October 2002, Vol. 100, No. 8, pp. 3037-3040 BRIEF REPORT Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin lymphoma outcome Przemyslaw Juszczynski, Ewa Kalinka, Jacques Bienvenu, Grzegorz Woszczek, Maciej Borowiec, Tadeusz Robak, Marek Kowalski, Ewa Lech-Maranda, Lucile Baseggio, Bertrand Coiffier, Gilles Salles, and Krzysztof Warzocha From the Department of Hematology and Department of Clinical Immunology, Medical University of Lodz, Poland, and Service d'Hematologie, Centre Hospitalier Lyon-Sud, and Jeune Equipe "Pathologie des Cellules Lymphoïdes" Université Claude Bernard, Lyon, France. Tumor necrosis factor (TNF) production and non-Hodgkin lymphoma (NHL) outcome was found to be related to the TNF308 polymorphism. To explore whether this could be linked to neighboring polymorphisms, we genotyped the TNF376,308,238,163, lymphotoxin alpha (LT)+252, and HLA DRB1 alleles in 204 patients with NHL and 120 controls. TNF308A was the only allele associated with higher TNF and its p55 and p75 receptors' levels (P = .009, P = .03, and P = .007) and lower complete remission rates (P = .006). Freedom from progression (FFP) and overall survival (OS) were shorter in patients with TNF308A (P = .009 and P = .02), null HLA DRB1*02 allele (P = .007 and P = .14), or both genetic markers (P = .004 and P = .005). Multivariate analysis incorporating International Prognostic Index (IPI) identified TNF308A (P < .0001, relative risk [RR] = 1.63; P < .0001, RR = 1.51) and null HLA DRB1*02 alleles (P = .015, RR = 1.18; P < .0001, RR = 1.25) as independent factors for FFP and OS. 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