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Prepublished online as a Blood First Edition Paper on June 21, 2002; DOI 10.1182/blood-2002-04-1104. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1104v1 100/9/3077    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Li, Q. Articles by Stamatoyannopoulos, G. Search for Related Content PubMed PubMed Citation Articles by Li, Q. Articles by Stamatoyannopoulos, G. Related Collections Hematopoiesis and Stem Cells Gene Expression Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 November 2002, Vol. 100, No. 9, pp. 3077-3086 REVIEW ARTICLE Locus control regions Qiliang Li, Kenneth R. Peterson, Xiangdong Fang, and George Stamatoyannopoulos From the Division of Medical Genetics and Department of Genome Sciences, University of Washington, Seattle, and the Department of Biochemistry and Molecular Biology and the Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City. Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. Although their composition and locations relative to their cognate genes are different, LCRs have been described in a broad spectrum of mammalian gene systems, suggesting that they play an important role in the control of eukaryotic gene expression. The discovery of the LCR in the -globin locus and the characterization of LCRs in other loci reinforces the concept that developmental and cell lineage-specific regulation of gene expression relies not on gene-proximal elements such as promoters, enhancers, and silencers exclusively, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Narlikar and I. Ovcharenko Identifying regulatory elements in eukaryotic genomes Brief Funct Genomic Proteomic, June 4, 2009; (2009) elp014v1. [Abstract] [Full Text] [PDF] M. Brazdova, T. Quante, L. Togel, K. Walter, C. 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