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Prepublished online as a Blood First Edition Paper on June 21, 2002; DOI 10.1182/blood-2002-04-1104. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1104v1 100/9/3077    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Li, Q. Articles by Stamatoyannopoulos, G. Search for Related Content PubMed PubMed Citation Articles by Li, Q. Articles by Stamatoyannopoulos, G. Related Collections Hematopoiesis and Stem Cells Gene Expression Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 November 2002, Vol. 100, No. 9, pp. 3077-3086 REVIEW ARTICLE Locus control regions Qiliang Li, Kenneth R. Peterson, Xiangdong Fang, and George Stamatoyannopoulos From the Division of Medical Genetics and Department of Genome Sciences, University of Washington, Seattle, and the Department of Biochemistry and Molecular Biology and the Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City. Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. Although their composition and locations relative to their cognate genes are different, LCRs have been described in a broad spectrum of mammalian gene systems, suggesting that they play an important role in the control of eukaryotic gene expression. The discovery of the LCR in the -globin locus and the characterization of LCRs in other loci reinforces the concept that developmental and cell lineage-specific regulation of gene expression relies not on gene-proximal elements such as promoters, enhancers, and silencers exclusively, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Ranatunga, C. M. Hedrich, F. Wang, D. W. McVicar, N. Nowak, T. Joshi, L. Feigenbaum, L. R. Grant, S. Stager, and J. H. 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Li Synergistic and Additive Properties of the Beta-Globin Locus Control Region (LCR) Revealed by 5'HS3 Deletion Mutations: Implication for LCR Chromatin Architecture Mol. Cell. Biol., August 15, 2005; 25(16): 7033 - 7041. [Abstract] [Full Text] [PDF] D. C. King, J. Taylor, L. Elnitski, F. Chiaromonte, W. Miller, and R. C. Hardison Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences Genome Res., August 1, 2005; 15(8): 1051 - 1060. [Abstract] [Full Text] [PDF] D. Feng and Y. W. Kan The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of {beta}-like globin genes PNAS, July 12, 2005; 102(28): 9896 - 9900. [Abstract] [Full Text] [PDF] T. Mijalski, A. Harder, T. Halder, M. Kersten, M. Horsch, T. M. Strom, H. V. Liebscher, F. Lottspeich, M. H. de Angelis, and J. Beckers Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues PNAS, June 14, 2005; 102(24): 8621 - 8626. [Abstract] [Full Text] [PDF] A. G. West and P. Fraser Remote control of gene transcription Hum. Mol. Genet., April 15, 2005; 14(suppl_1): R101 - R111. [Abstract] [Full Text] [PDF] Q. Li, D. W. Emery, H. Han, J. Sun, M. Yu, and G. Stamatoyannopoulos Differences of globin transgene expression in stably transfected cell lines and transgenic mice Blood, April 15, 2005; 105(8): 3346 - 3352. [Abstract] [Full Text] [PDF] T. Graslund, X. Li, L. Magnenat, M. Popkov, and C. F. Barbas III Exploring Strategies for the Design of Artificial Transcription Factors: TARGETING SITES PROXIMAL TO KNOWN REGULATORY REGIONS FOR THE INDUCTION OF {gamma}-GLOBIN EXPRESSION AND THE TREATMENT OF SICKLE CELL DISEASE J. Biol. Chem., February 4, 2005; 280(5): 3707 - 3714. [Abstract] [Full Text] [PDF] J. M. Lay, G. Bane, C. S. Brunkan, J. Davis, L. Lopez-Diaz, and L. C. Samuelson Enteroendocrine cell expression of a cholecystokinin gene construct in transgenic mice and cultured cells Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G354 - G361. [Abstract] [Full Text] [PDF] D. P. Steensma, R. J. Gibbons, and D. R. Higgs Acquired {alpha}-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies Blood, January 15, 2005; 105(2): 443 - 452. [Abstract] [Full Text] [PDF] R. P. Martins, G. C. Ostermeier, and S. A. Krawetz Nuclear Matrix Interactions at the Human Protamine Domain: A WORKING MODEL OF POTENTIATION J. Biol. Chem., December 10, 2004; 279(50): 51862 - 51868. [Abstract] [Full Text] [PDF] D. U. Lee and A. Rao Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3 PNAS, November 9, 2004; 101(45): 16010 - 16015. [Abstract] [Full Text] [PDF] S.-H. L. Kang, P. P Levings, F. Andersen, P. J Laipis, K. I Berns, R. T Zori, and J. Bungert Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human {beta}-globin transgene in a centromeric region Genes Cells, November 1, 2004; 9(11): 1043 - 1053. [Abstract] [Full Text] [PDF] M. Shnyreva, W. M. Weaver, M. Blanchette, S. L. Taylor, M. Tompa, D. R. Fitzpatrick, and C. B. Wilson Evolutionarily conserved sequence elements that positively regulate IFN-{gamma} expression in T cells PNAS, August 24, 2004; 101(34): 12622 - 12627. [Abstract] [Full Text] [PDF] W. Wagner, A. Ansorge, U. Wirkner, V. Eckstein, C. Schwager, J. Blake, K. Miesala, J. Selig, R. Saffrich, W. Ansorge, et al. Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis Blood, August 1, 2004; 104(3): 675 - 686. [Abstract] [Full Text] [PDF] C. A. Borgono, I. P. Michael, and E. P. Diamandis Human Tissue Kallikreins: Physiologic Roles and Applications in Cancer Mol. Cancer Res., May 1, 2004; 2(5): 257 - 280. [Abstract] [Full Text] [PDF] F. Harrow, J. U. Amuta, S. R. Hutchinson, F. Akwaa, and B. D. Ortiz Factors Binding a Non-classical Cis-element Prevent Heterochromatin Effects on Locus Control Region Activity J. Biol. Chem., April 23, 2004; 279(17): 17842 - 17849. [Abstract] [Full Text] [PDF] A. I. Su, T. Wiltshire, S. Batalov, H. Lapp, K. A. Ching, D. Block, J. Zhang, R. Soden, M. Hayakawa, G. Kreiman, et al. A gene atlas of the mouse and human protein-encoding transcriptomes PNAS, April 20, 2004; 101(16): 6062 - 6067. [Abstract] [Full Text] [PDF] A. P. Kimura, S. A. Liebhaber, and N. E. Cooke Epigenetic Modifications at the Human Growth Hormone Locus Predict Distinct Roles for Histone Acetylation and Methylation in Placental Gene Activation Mol. Endocrinol., April 1, 2004; 18(4): 1018 - 1032. [Abstract] [Full Text] [PDF] E. G. Schuetz Lessons from the CYP3A4 Promoter Mol. Pharmacol., February 1, 2004; 65(2): 279 - 281. [Full Text] [PDF] P. R. Cook Nongenic transcription, gene regulation and action at a distance J. Cell Sci., November 15, 2003; 116(22): 4483 - 4491. [Abstract] [Full Text] [PDF] A. Ozturk, A. Fresnoza, A. Savoie, H. W. Duckworth, and M. L. Duckworth Defining Regulatory Regions in the Rat Prolactin Gene Family Locus Using a Large P1 Genomic Clone Endocrinology, November 1, 2003; 144(11): 4742 - 4754. [Abstract] [Full Text] [PDF] R. van Driel, P. F. Fransz, and P. J. Verschure The eukaryotic genome: a system regulated at different hierarchical levels J. Cell Sci., October 15, 2003; 116(20): 4067 - 4075. [Abstract] [Full Text] [PDF] R.C. HARDISON, F. CHIAROMONTE, D. KOLBE, H. WANG, H. PETRYKOWSKA, L. ELNITSKI, S. YANG, B. GIARDINE, Y. ZHANG, C. RIEMER, et al. Global Predictions and Tests of Erythroid Regulatory Regions Cold Spring Harb Symp Quant Biol, January 1, 2003; 68(0): 335 - 344. [Abstract] [PDF]

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