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Prepublished online as a Blood First Edition Paper on June 21, 2002; DOI 10.1182/blood-2002-02-0502. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-02-0502v1 100/9/3193    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jay, K. E. Articles by Bhatia, M. Search for Related Content PubMed PubMed Citation Articles by Jay, K. E. Articles by Bhatia, M. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 November 2002, Vol. 100, No. 9, pp. 3193-3202 HEMATOPOIESIS Emergence of muscle and neural hematopoiesis in humans Karen E. Jay, Lisa Gallacher, and Mickie Bhatia From the John P. Robarts Research Institute, Developmental Stem Cell Biology, The University of Western Ontario, and the Fetal Medicine Division, St Joseph's Hospital and London Health Sciences Center, London, ON, Canada. During human development, hematopoiesis is thought to be compartmentalized to the fetal circulation, liver, and bone marrow. Here, we show that combinations of cytokines together with bone morphogenetic protein-4 and erythropoietin could induce multiple blood lineages from human skeletal muscle or neural tissue. Under defined serum-free conditions, the growth factors requirements, proliferation, and differentiation capacity of muscle and neural hematopoiesis were distinct to that derived from committed hematopoietic sites and were uniquely restricted to CD45CD34 cells expressing the prominin AC133. Our study defines epigenetic factors required for the emergence of hematopoiesis from unexpected tissue origins and illustrates that embyronically specified microenvironments do not limit cell fate in humans. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Jeanpierre, F. E. Nicolini, B. Kaniewski, C. Dumontet, R. Rimokh, A. Puisieux, and V. Maguer-Satta BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling Blood, October 15, 2008; 112(8): 3154 - 3163. [Abstract] [Full Text] [PDF] Y. M. Berkmen and B. A. Zalta Case 126: Extramedullary Hematopoiesis Radiology, December 1, 2007; 245(3): 905 - 908. [Full Text] [PDF] M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis J. Cell Sci., October 1, 2005; 118(19): 4343 - 4352. [Abstract] [Full Text] [PDF] S. Martinovic, S. Mazic, V. Kisic, N. Basic, J. Jakic-Razumovic, F. Borovecki, D. Batinic, P. Simic, L. Grgurevic, B. Labar, et al. Expression of Bone Morphogenetic Proteins in Stromal Cells from Human Bone Marrow Long-term Culture J. Histochem. Cytochem., September 1, 2004; 52(9): 1159 - 1167. [Abstract] [Full Text] [PDF] H. M. Bond, M. Mesuraca, E. Carbone, P. Bonelli, V. Agosti, N. Amodio, G. De Rosa, M. Di Nicola, A. M. Gianni, M. A. S. Moore, et al. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells Blood, March 15, 2004; 103(6): 2062 - 2070. [Abstract] [Full Text] [PDF] R. Galli, A. Gritti, L. Bonfanti, and A. L. Vescovi Neural Stem Cells: An Overview Circ. Res., April 4, 2003; 92(6): 598 - 608. [Abstract] [Full Text] [PDF] G. Q. Daley, M. A. Goodell, and E. Y. Snyder Realistic Prospects for Stem Cell Therapeutics Hematology, January 1, 2003; 2003(1): 398 - 418. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020