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Prepublished online as a Blood First Edition Paper on August 15, 2002; DOI 10.1182/blood-2002-03-0921. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-03-0921v1 101/1/210    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by von Stebut, E. Articles by Maurer, M. Search for Related Content PubMed PubMed Citation Articles by von Stebut, E. Articles by Maurer, M. Related Collections Immunobiology Phagocytes Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2003, Vol. 101, No. 1, pp. 210-215 IMMUNOBIOLOGY Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1/ released from neutrophils recruited by mast cell-derived TNF Esther von Stebut, Martin Metz, Genevieve Milon, Jürgen Knop, and Marcus Maurer From the Department of Dermatology, University-Hospital Mainz, Germany; and Unite d'Immunophysiologie et Parasitisme Intracellulaire, Institut Pasteur, Paris, France. Macrophages (M) play a crucial role in the development of cutaneous granulomas (CGs) initiated by foreign bodies or invasive microorganisms. However, little is known about how M are recruited to sites of CG formation. To test whether mast cells (MCs) contribute to early M recruitment to developing granulomas, CGs were induced in MC-deficient KitW/KitW-v mice by injection of polyacrylamide gel (PAG). KitW/KitW-v mice as well as mice deficient in the MC product TNF exhibited markedly reduced M numbers in CGs. M recruitment was restored in KitW/KitW-v mice reconstituted with MCs from Kit+/+ or TNF+/+, but not from TNF/ mice. MC-TNF-dependent M influx required prior recruitment of MIP-1/-producing neutrophils (PMNs), as PMN depletion before induction of CGs completely inhibited M influx, which was restored after reconstitution with PMN supernatants. These findings indicate that M recruitment to cutaneous PAG- induced granulomas is the result of a sequence of inflammatory processes initiated by MC-derived TNF followed by PMN influx and MIP-1a/ release. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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