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Prepublished online as a Blood First Edition Paper on June 28, 2002; DOI 10.1182/blood-2002-04-1188.
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Blood, 1 January 2003, Vol. 101, No. 1, pp. 289-291
NEOPLASIA
Brief report
Centrosome aberrations in acute myeloid leukemia are
correlated with cytogenetic risk profile
Kai Neben,
Christian Giesecke,
Silja Schweizer,
Anthony D. Ho, and
Alwin Krämer
From the Medizinische Klinik und Poliklinik V,
Universität Heidelberg, Heidelberg, Germany.
Genetic instability is a common feature in acute myeloid leukemia
(AML). Centrosome aberrations have been described as a possible cause
of aneuploidy in many human tumors. To investigate whether centrosome
aberrations correlate with cytogenetic findings in AML, we examined
a set of 51 AML samples by using a centrosome-specific antibody to
pericentrin. All 51 AML samples analyzed displayed numerical and
structural centrosome aberrations (36.0% ± 16.6%) as
compared with peripheral blood mononuclear cells from 21 healthy volunteers (5.2% ± 2.0%; P < .0001). In comparison
to AML samples with normal chromosome count, the extent of numerical
and structural centrosome aberrations was higher in samples with
numerical chromosome changes (50.5% ± 14.2% versus
34.3% ± 12.2%; P < .0001). When the frequency of
centrosome aberrations was analyzed within cytogenetically defined risk
groups, we found a correlation of the extent of centrosome abnormalities to all 3 risk groups (P = .0015), defined
as favorable (22.5% ± 7.3%), intermediate (35.3% ± 13.1%),
and adverse (50.3% ± 15.6%). These results indicate that
centrosome defects may contribute to the acquisition of chromosome
aberrations and thereby to the prognosis in AML.
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