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 Prepublished online as a Blood First Edition Paper on August 15, 2002; DOI 10.1182/blood-2002-03-0894.

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Blood, 1 January 2003, Vol. 101, No. 1, pp. 292-294

NEOPLASIA
Brief report

Monoglycerides induce apoptosis in human leukemic cells while sparing normal peripheral blood mononuclear cells

Fabianne Philippoussis, Chantal Arguin, Véronique Mateo, Ann-Muriel Steff, and Patrice Hugo

From PROCREA BioSciences, Division of Research and Development; Department of Microbiology and Immunology, McGill University; and Laboratoire d'Allergie, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Université de Montréal; all of Montréal, QC, Canada.

A major drawback of the current antineoplastic treatments is their lack of specificity toward cancer cells, because they are most often cytotoxic to normal cells, thus creating related side effects. Hence, the identification of new apoptosis-inducing agents, specifically targeting malignant cells while sparing their normal counterparts, is of crucial interest. We show here that monoglycerides, a family of lipids consisting of a single fatty acid attached to a glycerol backbone, induce cell death in several human leukemic cell lines. Importantly, treatment of primary leukemic cells, obtained from B-cell chronic lymphocytic leukemia patients, resulted in rapid apoptosis. In striking contrast, resting or activated human peripheral blood mononuclear cells from healthy individuals were resistant to the same treatment. Therefore, these compounds could represent potential antileukemic drugs or could allow for the design of novel therapeutic agents applied to leukemia.

© 2003 by The American Society of Hematology.
 

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