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Prepublished online as a Blood First Edition Paper on August 1, 2002; DOI 10.1182/blood-2002-04-1131. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1131v1 101/1/318    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Da Costa, L. Articles by Mohandas, N. Search for Related Content PubMed PubMed Citation Articles by Da Costa, L. Articles by Mohandas, N. Related Collections Hematopoiesis and Stem Cells Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2003, Vol. 101, No. 1, pp. 318-324 RED CELLS Ribosomal protein S19 expression during erythroid differentiation Lydie Da Costa, Goutham Narla, Thiébaut-Noel Willig, Luanne L. Peters, Marilyn Parra, Jason Fixler, Gil Tchernia, and Narla Mohandas From the New York Blood Center and Mount Sinaï Medical Center, NY; the Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA; The Jackson Laboratory, Bar Harbor, ME; and the Laboratoire d'Hématologie, AP-HP, Faculté de Médecine Paris XI, INSERM U473, Hôpital de Bicêtre, Le Kremlin Bicêtre, France. The gene encoding ribosomal protein S19 (RPS19) has been shown to be mutated in 25% of the patients affected by Diamond-Blackfan anemia (DBA), a congenital erythroblastopenia. As the role of RPS19 in erythropoiesis is still to be defined, we performed studies on RPS19 expression during terminal erythroid differentiation. Comparative analysis of the genomic sequences of human and mouse RPS19 genes enabled the identification of 4 conserved sequence elements in the 5' region. Characterization of transcriptional elements allowed the identification of the promoter in the human RPS19 gene and the localization of a strong regulatory element in the third conserved sequence element. By Northern blot and Western blot analyses of murine splenic erythroblasts infected with the anemia-inducing strain Friend virus (FAV cells), RPS19 mRNA and protein expression were shown to decrease during terminal erythroid differentiation. We anticipate that these findings will contribute to further development of our understanding of the contribution of RPS19 to erythropoiesis. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Flygare and S. Karlsson Diamond-Blackfan anemia: erythropoiesis lost in translation Blood, April 15, 2007; 109(8): 3152 - 3154. [Abstract] [Full Text] [PDF] S. Orru, A. Aspesi, M. Armiraglio, M. Caterino, F. Loreni, M. Ruoppolo, C. Santoro, and I. Dianzani Analysis of the Ribosomal Protein S19 Interactome Mol. Cell. Proteomics, March 1, 2007; 6(3): 382 - 393. [Abstract] [Full Text] [PDF] S. G. Roh, M. Kuno, D. Hishikawa, Y. H. Hong, K. Katoh, Y. Obara, H. Hidari, and S. Sasaki Identification of differentially expressed transcripts in bovine rumen and abomasum using a differential display method J Anim Sci, February 1, 2007; 85(2): 395 - 403. [Abstract] [Full Text] [PDF] J. Flygare, A. Aspesi, J. C. Bailey, K. Miyake, J. M. Caffrey, S. Karlsson, and S. R. Ellis Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits Blood, February 1, 2007; 109(3): 980 - 986. [Abstract] [Full Text] [PDF] V. Choesmel, D. Bacqueville, J. Rouquette, J. Noaillac-Depeyre, S. Fribourg, A. Cretien, T. Leblanc, G. Tchernia, L. Da Costa, and P.-E. Gleizes Impaired ribosome biogenesis in Diamond-Blackfan anemia Blood, February 1, 2007; 109(3): 1275 - 1283. [Abstract] [Full Text] [PDF] H. T. Gazda, A. T. Kho, D. Sanoudou, J. M. Zaucha, I. S. Kohane, C. A. Sieff, and A. H. Beggs Defective Ribosomal Protein Gene Expression Alters Transcription, Translation, Apoptosis, and Oncogenic Pathways in Diamond-Blackfan Anemia Stem Cells, September 1, 2006; 24(9): 2034 - 2044. [Abstract] [Full Text] [PDF] B. L. Ebert, M. M. Lee, J. L. Pretz, A. Subramanian, R. Mak, T. R. Golub, and C. A. Sieff An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray Blood, June 15, 2005; 105(12): 4620 - 4626. [Abstract] [Full Text] [PDF] J. Flygare, T. Kiefer, K. Miyake, T. Utsugisawa, I. Hamaguchi, L. Da Costa, J. Richter, E. J. Davey, H. Matsson, N. Dahl, et al. Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia Blood, June 15, 2005; 105(12): 4627 - 4634. [Abstract] [Full Text] [PDF] L. Da Costa, G. Tchernia, P. Gascard, A. Lo, J. Meerpohl, C. Niemeyer, J.-A. Chasis, J. Fixler, and N. Mohandas Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology Blood, June 15, 2003; 101(12): 5039 - 5045. [Abstract] [Full Text] [PDF]

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