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Prepublished online as a Blood First Edition Paper on January 16, 2003; DOI 10.1182/blood-2002-11-3353. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-11-3353v1 101/10/4000    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stebbing, J. Articles by Patterson, S. Search for Related Content PubMed PubMed Citation Articles by Stebbing, J. Articles by Patterson, S. Related Collections Immunobiology Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2003, Vol. 101, No. 10, pp. 4000-4004 IMMUNOBIOLOGY The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors Justin Stebbing, Brian Gazzard, Louise Kim, Simon Portsmouth, Adrian Wildfire, Ian Teo, Mark Nelson, Mark Bower, Frances Gotch, Sunil Shaunak, Pramod Srivastava, and Steve Patterson From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London; the Department of Infectious Diseases, Division of Investigative Science, Faculty of Medicine, Imperial College at Hammersmith Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington. A small proportion of patients with human immunodeficiency virus type 1 (HIV-1) remains asymptomatic for a long period after infection. It is thought that a vigorous immune response may contribute to long-term nonprogression, though studies are confounded by heterogeneity among patients. We studied the levels of HIV-1 receptors, costimulatory T-cell molecules, and dendritic cell (DC) numbers in 18 patients with long-term infection, CD4 counts greater than 400 cells/mm3, and HIV-1 viral loads lower than 50 copies/mL. These patients were further differentiated through the presence or absence of 2-LTR DNA circles, a possible marker for residual ongoing HIV-1 replication. A statistically significant increase in levels of CD91, the heat-shock protein (HSP) receptor, was observed in therapy-naive patients who had no evidence of ongoing viral replication (P = .01). This difference was most notable on their monocytes. High levels of CD91 may be a host factor that contributes to the maintenance of long-term nonprogression. The ability of CD91 to internalize -defensins and to cross-present exogenous antigen to cytotoxic T lymphocytes through major histocompatibility complex (MHC) class 1 may maintain CD8+ responses in these patients. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. Gong, W. Gai, J. Xu, W. Zhou, and P. Tien Glycoprotein 96-Mediated Presentation of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human Leukocyte Antigen Class I-Restricted Peptide and Humoral Immune Responses to HIV-1 p24 Clin. Vaccine Immunol., November 1, 2009; 16(11): 1595 - 1600. [Abstract] [Full Text] [PDF] E. Acheampong, Z. Parveen, A. Mengistu, N. Ngoubilly, B. Wigdahl, A. S. Lossinsky, R. J. Pomerantz, and M. Mukhtar Cholesterol-Depleting Statin Drugs Protect Postmitotically Differentiated Human Neurons against Ethanol- and Human Immunodeficiency Virus Type 1-Induced Oxidative Stress In Vitro J. Virol., February 1, 2007; 81(3): 1492 - 1501. [Abstract] [Full Text] [PDF] J. Stebbing and M. Bower Opposing roles of dendritic cell subsets in HIV-1 infection Blood, September 15, 2006; 108(6): 1785 - 1786. [Full Text] [PDF] A. Kebba, J. Stebbing, S. Rowland, R. Ingram, J. Agaba, S. Patterson, P. Kaleebu, N. Imami, and F. Gotch Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects J. Leukoc. Biol., July 1, 2005; 78(1): 37 - 42. [Abstract] [Full Text] [PDF] D. SenGupta, P. J. Norris, T. J. Suscovich, M. Hassan-Zahraee, H. F. Moffett, A. Trocha, R. Draenert, P. J. R. Goulder, R. J. Binder, D. L. Levey, et al. Heat Shock Protein-Mediated Cross-Presentation of Exogenous HIV Antigen on HLA Class I and Class II J. Immunol., August 1, 2004; 173(3): 1987 - 1993. [Abstract] [Full Text] [PDF] R. J. Binder and P. K. Srivastava Essential role of CD91 in re-presentation of gp96-chaperoned peptides PNAS, April 20, 2004; 101(16): 6128 - 6133. [Abstract] [Full Text] [PDF] J. Stebbing, B. Gazzard, S. Patterson, M. Bower, D. Perumal, M. Nelson, A. McMichael, G. Ogg, A. Epenetos, F. Gotch, et al. Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination Blood, March 1, 2004; 103(5): 1791 - 1795. [Abstract] [Full Text] [PDF] J. Stebbing, P. Savage, S. Patterson, and B. Gazzard All for CD91 and CD91 for all J. Antimicrob. Chemother., January 1, 2004; 53(1): 1 - 3. [Abstract] [Full Text] [PDF] J. Stebbing, B. Gazzard, S. Portsmouth, F. Gotch, L. Kim, M. Bower, S. Mandalia, R. Binder, P. Srivastava, and S. Patterson Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor Blood, September 1, 2003; 102(5): 1806 - 1814. [Abstract] [Full Text] [PDF]

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