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Prepublished online as a Blood First Edition Paper on January 23, 2003; DOI 10.1182/blood-2002-07-2290. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-07-2290v1 101/10/4219    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kimura, S. Articles by Maekawa, T. Search for Related Content PubMed PubMed Citation Articles by Kimura, S. Articles by Maekawa, T. Related Collections Immunobiology Neoplasia Transplantation Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2003, Vol. 101, No. 10, pp. 4219-4221 TRANSPLANTATION Brief report Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma Shinya Kimura, Akeyo Horie, Yoshiyuki Hiki, Chie Yamamoto, Satoru Suzuki, Junya Kuroda, Masayo Deguchi, Gen-ichi Kato, Takahiro Karasuno, Akira Hiraoka, Toshikazu Yoshikawa, and Taira Maekawa From the Department of Transfusion Medicine, Kyoto University Hospital, Kyoto, Japan; Department of Medicine, Daiko Medical Center, Daiko, Japan; Department of Clinical and Laboratory Medicine, Fukui Medical University, Fukui, Japan; Kyoto Second Red Cross Hospital, Kyoto, Japan; Fifth Department of Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan; and First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. We describe herein a case of nephrotic syndrome (NS) following allogeneic bone marrow transplantation (allo-BMT) for natural killer cell leukemia/lymphoma. Histologic studies defined the diagnosis as crescentic glomerulonephritis with massive immunoglobulin A (IgA) deposition, which has never been reported in NS cases following allo-BMT. Most of the massive infiltrated cells in the interstice were CD3+CD4CD8+ T cells derived from the donor. We observed mesangial deposition of Haemophilus parainfluenza outer membrane (OMHP) antigen and decreased glycosylation of the IgA1 hinge in the recipient's samples is consistent with the recently reported pathogenesis of IgA nephropathy. Further, the titer of IgA antibody against the donor serum was as high as other IgA nephropathy cases. These findings suggest that NS and crescentic glomerulonephritis in this case occurred as one of the forms of chronic graft-versus-host disease (GVHD), and that IgA deposition was associated with H parainfluenza and decreased glycosylation of the IgA1 hinge. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Brukamp, A. M. Doyle, R. D. Bloom, N. Bunin, J. E. Tomaszewski, and B. Cizman Nephrotic Syndrome after Hematopoietic Cell Transplantation: Do Glomerular Lesions Represent Renal Graft-versus-Host Disease? Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 685 - 694. [Abstract] [Full Text] [PDF] J. Kuroda, S. Kimura, H. Segawa, Y. Kobayashi, T. Yoshikawa, Y. Urasaki, T. Ueda, F. Enjo, H. Tokuda, O. G. Ottmann, et al. The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate Blood, September 15, 2003; 102(6): 2229 - 2235. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020