SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on February 6, 2003; DOI 10.1182/blood-2002-11-3577. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-11-3577v1 101/11/4260    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Geginat, J. Articles by Sallusto, F. Search for Related Content PubMed PubMed Citation Articles by Geginat, J. Articles by Sallusto, F. Related Collections Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 June 2003, Vol. 101, No. 11, pp. 4260-4266 CHEMOKINES Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines Jens Geginat, Antonio Lanzavecchia, and Federica Sallusto From the Institute for Research in Biomedicine, Bellinzona, Switzerland. Four human CD8+ T-cell subsets, naive (CCR7+CD45RA+), central memory (TCM, CCR7+CD45RA–), effector memory (TEM, CCR7–CD45RA–), and CD45RA+ effector memory cells (TEMRA, CCR7–CD45RA+) were compared for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Cytokine responsiveness and interleukin-15 receptor expression were low in naive T cells and progressively increased from TCM to TEM and TEMRA. In contrast, the capacity to accumulate in response to T-cell receptor (TCR) or cytokine stimulation showed a reciprocal pattern and was associated with resistance to cell death and Bcl-2 expression. Whereas all TCR-stimulated cells acquired a CD45RA–CCR7– phenotype, cytokine-stimulated cells maintained their phenotype with the exception of TCM cells, which expressed CCR7, CD45RA, and perforin in various combinations. Single CD8+ TCM cells, but not TEM cells, could be expanded with cytokines, and the obtained clones displayed several distinct phenotypes, suggesting that TCM cells are heterogeneous. Consistently, CCR4 expression in the CD8+ TCM pool discriminated CCR4+ type 2 polarized cells (Tc2) and CCR4–CTL precursors. Finally, ex vivo bromodeoxyuridine (BrdU) incorporation experiments revealed that memory subsets have different in vivo proliferation rates, with CCR4–TCM having the highest turnover and TEMRA the lowest. These results show that human CD8+ memory T-cell subsets have different proliferation and differentiation potentials in vitro and in vivo. Furthermore, they suggest that TEMRA cells are generated from a TCM subset upon homeostatic proliferation in the absence of antigen. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Berger, M. Berger, R. C. Hackman, M. Gough, C. Elliott, M. C. Jensen, and S. R. Riddell Safety and immunologic effects of IL-15 administration in nonhuman primates Blood, September 17, 2009; 114(12): 2417 - 2426. [Abstract] [Full Text] [PDF] A. L. A. Oliveira, H. Hayakawa, D. Schor, A. C. C. B. Leite, O. M. Espindola, A. Waters, J. Dean, D. G. Doherty, A. Q.-C. Araujo, and W. W. Hall High Frequencies of Functionally Competent Circulating Tax-Specific CD8+ T Cells in Human T Lymphotropic Virus Type 2 Infection J. Immunol., September 1, 2009; 183(5): 2957 - 2965. [Abstract] [Full Text] [PDF] S. Gupta, S. Agrawal, and S. Gollapudi Differential Effect of Human Herpesvirus 6A on Cell Division and Apoptosis among Naive and Central and Effector Memory CD4+ and CD8+ T-Cell Subsets J. Virol., June 1, 2009; 83(11): 5442 - 5450. [Abstract] [Full Text] [PDF] H. J. Ramos, A. M. Davis, A. G. Cole, J. D. Schatzle, J. Forman, and J. D. Farrar Reciprocal responsiveness to interleukin-12 and interferon-{alpha} specifies human CD8+ effector versus central memory T-cell fates Blood, May 28, 2009; 113(22): 5516 - 5525. [Abstract] [Full Text] [PDF] T. Kondo and M. Takiguchi Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines Int. Immunol., May 1, 2009; 21(5): 523 - 532. [Abstract] [Full Text] [PDF] E. B. Walker, W. Miller, D. Haley, K. Floyd, B. Curti, and W. J. Urba Characterization of the Class I-Restricted gp100 Melanoma Peptide-stimulated Primary Immune Response in Tumor-Free Vaccine-draining Lymph Nodes and Peripheral Blood Clin. Cancer Res., April 1, 2009; 15(7): 2541 - 2551. [Abstract] [Full Text] [PDF] S. Kuttruff, S. Koch, A. Kelp, G. Pawelec, H.-G. Rammensee, and A. Steinle NKp80 defines and stimulates a reactive subset of CD8 T cells Blood, January 8, 2009; 113(2): 358 - 369. [Abstract] [Full Text] [PDF] A. M. Crawley, T. Katz, K. Parato, and J. B. Angel IL-2 receptor {gamma} chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T cell division and susceptibility to apoptosis Int. Immunol., January 1, 2009; 21(1): 29 - 42. [Abstract] [Full Text] [PDF] J. G. Casado, O. DelaRosa, G. Pawelec, E. Peralbo, E. Duran, F. Barahona, R. Solana, and R. Tarazona Correlation of effector function with phenotype and cell division after in vitro differentiation of naive MART-1-specific CD8+ T cells Int. Immunol., January 1, 2009; 21(1): 53 - 62. [Abstract] [Full Text] [PDF] M. A. DeBenedette, D. M. Calderhead, H. Ketteringham, A. H. Gamble, J. M. Horvatinovich, I. Y. Tcherepanova, C. A. Nicolette, and D. G. Healey Priming of a Novel Subset of CD28+ Rapidly Expanding High-Avidity Effector Memory CTL by Post Maturation Electroporation-CD40L Dendritic Cells Is IL-12 Dependent J. Immunol., October 15, 2008; 181(8): 5296 - 5305. [Abstract] [Full Text] [PDF] M. Mehling, V. Brinkmann, J. Antel, A. Bar-Or, N. Goebels, C. Vedrine, C. Kristofic, J. Kuhle, R.L.P. Lindberg, and L. Kappos FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis Neurology, October 14, 2008; 71(16): 1261 - 1267. [Abstract] [Full Text] [PDF] R. Zappasodi, M. Di Nicola, C. Carlo-Stella, R. Mortarini, A. Molla, C. Vegetti, S. Albani, A. Anichini, and A. M. Gianni The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells Haematologica, October 1, 2008; 93(10): 1523 - 1534. [Abstract] [Full Text] [PDF] Y. Zhang, T. Ohkuri, D. Wakita, Y. Narita, K. Chamoto, H. Kitamura, and T. Nishimura Sialyl lewisx antigen-expressing human CD4+ T and CD8+ T cells as initial immune responders in memory phenotype subsets J. Leukoc. Biol., September 1, 2008; 84(3): 730 - 735. [Abstract] [Full Text] [PDF] E. B. Walker, D. Haley, U. Petrausch, K. Floyd, W. Miller, N. Sanjuan, G. Alvord, B. A. Fox, and W. J. Urba Phenotype and Functional Characterization of Long-term gp100-Specific Memory CD8+ T Cells in Disease-Free Melanoma Patients Before and After Boosting Immunization Clin. Cancer Res., August 15, 2008; 14(16): 5270 - 5283. [Abstract] [Full Text] [PDF] N. C. Brembilla, J. Weber, D. Rimoldi, S. Pradervand, F. Schutz, G. Pantaleo, C. Ruegg, M. Quadroni, K. Harshman, and M.-A. Doucey c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells Blood, August 1, 2008; 112(3): 652 - 660. [Abstract] [Full Text] [PDF] A. Serra, S. Nuti, S. Tavarini, C. Sammicheli, D. Rosa, G. Saletti, E. Soldaini, S. Abrignani, and A. Wack Coligation of the Hepatitis C Virus Receptor CD81 with CD28 Primes Naive T Lymphocytes to Acquire Type 2 Effector Function J. Immunol., July 1, 2008; 181(1): 174 - 185. [Abstract] [Full Text] [PDF] A. P. Soares, T. J. Scriba, S. Joseph, R. Harbacheuski, R. A. Murray, S. J. Gelderbloem, A. Hawkridge, G. D. Hussey, H. Maecker, G. Kaplan, et al. Bacillus Calmette-Guerin Vaccination of Human Newborns Induces T Cells with Complex Cytokine and Phenotypic Profiles J. Immunol., March 1, 2008; 180(5): 3569 - 3577. [Abstract] [Full Text] [PDF] D. Lilleri, C. Fornara, A. Chiesa, D. Caldera, E. P. Alessandrino, and G. Gerna Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection Haematologica, February 1, 2008; 93(2): 248 - 256. [Abstract] [Full Text] [PDF] S. Deola, M. C. Panelli, D. Maric, S. Selleri, N. I. Dmitrieva, C. Y. Voss, H. Klein, D. Stroncek, E. Wang, and F. M. Marincola Helper B Cells Promote Cytotoxic T Cell Survival and Proliferation Independently of Antigen Presentation through CD27/CD70 Interactions J. Immunol., February 1, 2008; 180(3): 1362 - 1372. [Abstract] [Full Text] [PDF] E. C. P. Waller, N. McKinney, R. Hicks, A. J. Carmichael, J. G. P. Sissons, and M. R. Wills Differential costimulation through CD137 (4 1BB) restores proliferation of human virus-specific "effector memory" (CD28 CD45RAHI) CD8+ T cells Blood, December 15, 2007; 110(13): 4360 - 4366. [Abstract] [Full Text] [PDF] P. Trzonkowski, A. Debska-Slizien, A. Mysliwski, and B. Rutkowski Treatment with recombinant human erythropoietin is associated with rejuvenation of CD8+ T cell compartment in chronic renal failure patients Nephrol. Dial. Transplant., November 1, 2007; 22(11): 3221 - 3227. [Abstract] [Full Text] [PDF] G. Filaci, D. Fenoglio, M. Fravega, G. Ansaldo, G. Borgonovo, P. Traverso, B. Villaggio, A. Ferrera, A. Kunkl, M. Rizzi, et al. CD8+CD28 T Regulatory Lymphocytes Inhibiting T Cell Proliferative and Cytotoxic Functions Infiltrate Human Cancers J. Immunol., October 1, 2007; 179(7): 4323 - 4334. [Abstract] [Full Text] [PDF] G. Cassese, E. Parretta, L. Pisapia, A. Santoni, J. Guardiola, and F. Di Rosa Bone marrow CD8 cells down-modulate membrane IL-7R{alpha} expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment. Blood, September 15, 2007; 110(6): 1960 - 1969. [Abstract] [Full Text] [PDF] S. Hao, Y. Liu, J. Yuan, X. Zhang, T. He, X. Wu, Y. Wei, D. Sun, and J. Xiang Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses J. Immunol., September 1, 2007; 179(5): 2731 - 2740. [Abstract] [Full Text] [PDF] C. M. Freeman, J. L. Curtis, and S. W. Chensue CC Chemokine Receptor 5 and CXC Chemokine Receptor 6 Expression by Lung CD8+ Cells Correlates with Chronic Obstructive Pulmonary Disease Severity Am. J. Pathol., September 1, 2007; 171(3): 767 - 776. [Abstract] [Full Text] [PDF] M. Jacobsen, A. K. Detjen, H. Mueller, A. Gutschmidt, S. Leitner, U. Wahn, K. Magdorf, and S. H. E. Kaufmann Clonal Expansion of CD8+ Effector T Cells in Childhood Tuberculosis J. Immunol., July 15, 2007; 179(2): 1331 - 1339. [Abstract] [Full Text] [PDF] R. B. Smeltz Profound Enhancement of the IL-12/IL-18 Pathway of IFN-{gamma} Secretion in Human CD8+ Memory T Cell Subsets via IL-15 J. Immunol., April 15, 2007; 178(8): 4786 - 4792. [Abstract] [Full Text] [PDF] M. A. Lima, A. Marzocchetti, P. Autissier, T. Tompkins, Y. Chen, J. Gordon, D. B. Clifford, R. T. Gandhi, N. Venna, J. R. Berger, et al. Frequency and Phenotype of JC Virus-Specific CD8+ T Lymphocytes in the Peripheral Blood of Patients with Progressive Multifocal Leukoencephalopathy J. Virol., April 1, 2007; 81(7): 3361 - 3368. [Abstract] [Full Text] [PDF] P. Romero, A. Zippelius, I. Kurth, M. J. Pittet, C. Touvrey, E. M. Iancu, P. Corthesy, E. Devevre, D. E. Speiser, and N. Rufer Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes J. Immunol., April 1, 2007; 178(7): 4112 - 4119. [Abstract] [Full Text] [PDF] M. Monteiro, C. Evaristo, A. Legrand, A. Nicoletti, and B. Rocha Cartography of gene expression in CD8 single cells: novel CCR7- subsets suggest differentiation independent of CD45RA expression Blood, April 1, 2007; 109(7): 2863 - 2870. [Abstract] [Full Text] [PDF] C. Barbey, P. Baumgaertner, E. Devevre, V. Rubio-Godoy, L. Derre, G. Bricard, P. Guillaume, I. F. Luescher, D. Lienard, J.-C. Cerottini, et al. IL-12 Controls Cytotoxicity of a Novel Subset of Self-Antigen-Specific Human CD28+ Cytolytic T Cells J. Immunol., March 15, 2007; 178(6): 3566 - 3574. [Abstract] [Full Text] [PDF] G.-Z. Liu, L.-B. Fang, P. Hjelmstrom, and X.-G. Gao Increased CD8+ central memory T cells in patients with multiple sclerosis Multiple Sclerosis, March 1, 2007; 13(2): 149 - 155. [Abstract] [PDF] P. Bejon, S. Keating, J. Mwacharo, O. K. Kai, S. Dunachie, M. Walther, T. Berthoud, T. Lang, J. Epstein, D. Carucci, et al. Early Gamma Interferon and Interleukin-2 Responses to Vaccination Predict the Late Resting Memory in Malaria-Naive and Malaria-Exposed Individuals Infect. Immun., November 1, 2006; 74(11): 6331 - 6338. [Abstract] [Full Text] [PDF] J. Carrasco, D. Godelaine, A. Van Pel, T. Boon, and P. van der Bruggen CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation Blood, November 1, 2006; 108(9): 2897 - 2905. [Abstract] [Full Text] [PDF] D. Xia, S. Hao, and J. Xiang CD8+ Cytotoxic T-APC Stimulate Central Memory CD8+ T Cell Responses via Acquired Peptide-MHC Class I Complexes and CD80 Costimulation, and IL-2 Secretion. J. Immunol., September 1, 2006; 177(5): 2976 - 2984. [Abstract] [Full Text] [PDF] A. T. Stock, C. M. Jones, W. R. Heath, and F. R. Carbone Cutting Edge: Central Memory T Cells Do Not Show Accelerated Proliferation or Tissue Infiltration in Response to Localized Herpes Simplex Virus-1 Infection J. Immunol., August 1, 2006; 177(3): 1411 - 1415. [Abstract] [Full Text] [PDF] N. Caccamo, S. Meraviglia, C. La Mendola, G. Guggino, F. Dieli, and A. Salerno Phenotypical and Functional Analysis of Memory and Effector Human CD8 T Cells Specific for Mycobacterial Antigens J. Immunol., August 1, 2006; 177(3): 1780 - 1785. [Abstract] [Full Text] [PDF] M. Heydtmann, D. Hardie, P. L. Shields, J. Faint, C. D. Buckley, J. J. Campbell, M. Salmon, and D. H. Adams Detailed Analysis of Intrahepatic CD8 T Cells in the Normal and Hepatitis C-Infected Liver Reveals Differences in Specific Populations of Memory Cells with Distinct Homing Phenotypes J. Immunol., July 1, 2006; 177(1): 729 - 738. [Abstract] [Full Text] [PDF] D. Sauce, M. Larsen, S. J. Curnow, A. M. Leese, P. A. H. Moss, A. D. Hislop, M. Salmon, and A. B. Rickinson EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15 Blood, July 1, 2006; 108(1): 11 - 18. [Abstract] [Full Text] [PDF] H.-R. Kim, M. S. Hong, J. M. Dan, and I. Kang Altered IL-7R{alpha} expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses Blood, April 1, 2006; 107(7): 2855 - 2862. [Abstract] [Full Text] [PDF] L. M. Serrano, T. Pfeiffer, S. Olivares, T. Numbenjapon, J. Bennitt, D. Kim, D. Smith, G. McNamara, Z. Al-Kadhimi, J. Rosenthal, et al. Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy Blood, April 1, 2006; 107(7): 2643 - 2652. [Abstract] [Full Text] [PDF] M. Migliaccio, P. M. S. Alves, P. Romero, and N. Rufer Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8+ T Lymphocyte Proliferation J. Immunol., February 15, 2006; 176(4): 2173 - 2182. [Abstract] [Full Text] [PDF] S. Beq, M.-T. Nugeyre, R. H. T. Fang, D. Gautier, R. Legrand, N. Schmitt, J. Estaquier, F. Barre-Sinoussi, B. Hurtrel, R. Cheynier, et al. IL-7 Induces Immunological Improvement in SIV-Infected Rhesus Macaques under Antiviral Therapy J. Immunol., January 15, 2006; 176(2): 914 - 922. [Abstract] [Full Text] [PDF] D. Baeten, S. Louis, C. Braud, C. Braudeau, C. Ballet, F. Moizant, A. Pallier, M. Giral, S. Brouard, and J.-P. Soulillou Phenotypically and Functionally Distinct CD8+ Lymphocyte Populations in Long-Term Drug-Free Tolerance and Chronic Rejection in Human Kidney Graft Recipients J. Am. Soc. Nephrol., January 1, 2006; 17(1): 294 - 304. [Abstract] [Full Text] [PDF] O. Gasser, A. Missiou, C. Eken, and C. Hess Human CD8+ T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation Blood, December 1, 2005; 106(12): 3718 - 3724. [Abstract] [Full Text] [PDF] E. Amyes, A. J. McMichael, and M. F. C. Callan Human CD4+ T Cells Are Predominantly Distributed among Six Phenotypically and Functionally Distinct Subsets J. Immunol., November 1, 2005; 175(9): 5765 - 5773. [Abstract] [Full Text] [PDF] T. Willinger, T. Freeman, H. Hasegawa, A. J. McMichael, and M. F. C. Callan Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets J. Immunol., November 1, 2005; 175(9): 5895 - 5903. [Abstract] [Full Text] [PDF] J. K. Ahn, H. Chung, D.-s. Lee, Y. S. Yu, and H. G. Yu CD8brightCD56+ T Cells Are Cytotoxic Effectors in Patients with Active Behcet's Uveitis J. Immunol., November 1, 2005; 175(9): 6133 - 6142. [Abstract] [Full Text] [PDF] U.-C. Meier, R. E. Owen, E. Taylor, A. Worth, N. Naoumov, C. Willberg, K. Tang, P. Newton, P. Pellegrino, I. Williams, et al. Shared Alterations in NK Cell Frequency, Phenotype, and Function in Chronic Human Immunodeficiency Virus and Hepatitis C Virus Infections J. Virol., October 1, 2005; 79(19): 12365 - 12374. [Abstract] [Full Text] [PDF] T. P.F. Gade, W. Hassen, E. Santos, G. Gunset, A. Saudemont, M. C. Gong, R. Brentjens, X.-S. Zhong, M. Stephan, J. Stefanski, et al. Targeted Elimination of Prostate Cancer by Genetically Directed Human T Lymphocytes Cancer Res., October 1, 2005; 65(19): 9080 - 9088. [Abstract] [Full Text] [PDF] J. Schwendemann, C. Choi, V. Schirrmacher, and P. Beckhove Dynamic Differentiation of Activated Human Peripheral Blood CD8+ and CD4+ Effector Memory T Cells J. Immunol., August 1, 2005; 175(3): 1433 - 1439. [Abstract] [Full Text] [PDF] D. Herndler-Brandstetter, S. Schwaiger, E. Veel, C. Fehrer, D. P. Cioca, G. Almanzar, M. Keller, G. Pfister, W. Parson, R. Wurzner, et al. CD25-Expressing CD8+ T Cells Are Potent Memory Cells in Old Age J. Immunol., August 1, 2005; 175(3): 1566 - 1574. [Abstract] [Full Text] [PDF] N. L. Alves, F. A. Arosa, and R. A. W. van Lier IL-21 Sustains CD28 Expression on IL-15-Activated Human Naive CD8+ T Cells J. Immunol., July 15, 2005; 175(2): 755 - 762. [Abstract] [Full Text] [PDF] P. J. Dunne, L. Belaramani, J. M. Fletcher, S. F. de Mattos, M. Lawrenz, M. V. D. Soares, M. H. A. Rustin, E. W.-F. Lam, M. Salmon, and A. N. Akbar Quiescence and functional reprogramming of Epstein-Barr virus (EBV)-specific CD8+ T cells during persistent infection Blood, July 15, 2005; 106(2): 558 - 565. [Abstract] [Full Text] [PDF] K. Schilbach, G. Kerst, S. Walter, M. Eyrich, D. Wernet, R. Handgretinger, W. Xie, H.-G. Rammensee, I. Muller, H.-J. Buhring, et al. Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction Blood, July 1, 2005; 106(1): 144 - 149. [Abstract] [Full Text] [PDF] M. Migliaccio, K. Raj, O. Menzel, and N. Rufer Mechanisms That Limit the In Vitro Proliferative Potential of Human CD8+ T Lymphocytes J. Immunol., March 15, 2005; 174(6): 3335 - 3343. [Abstract] [Full Text] [PDF] M. Paiardini, B. Cervasi, H. Albrecht, A. Muthukumar, R. Dunham, S. Gordon, H. Radziewicz, G. Piedimonte, M. Magnani, M. Montroni, et al. Loss of CD127 Expression Defines an Expansion of Effector CD8+ T Cells in HIV-Infected Individuals J. Immunol., March 1, 2005; 174(5): 2900 - 2909. [Abstract] [Full Text] [PDF] C. Bouneaud, Z. Garcia, P. Kourilsky, and C. Pannetier Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo J. Exp. Med., February 22, 2005; 201(4): 579 - 590. [Abstract] [Full Text] [PDF] C. Hess, T. K. Means, P. Autissier, T. Woodberry, M. Altfeld, M. M. Addo, N. Frahm, C. Brander, B. D. Walker, and A. D. Luster IL-8 responsiveness defines a subset of CD8 T cells poised to kill Blood, December 1, 2004; 104(12): 3463 - 3471. [Abstract] [Full Text] [PDF] L. Rivino, M. Messi, D. Jarrossay, A. Lanzavecchia, F. Sallusto, and J. Geginat Chemokine Receptor Expression Identifies Pre-T Helper (Th)1, Pre-Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells J. Exp. Med., September 20, 2004; 200(6): 725 - 735. [Abstract] [Full Text] [PDF] M. Moniuszko, T. Fry, W.-P. Tsai, M. Morre, B. Assouline, P. Cortez, M. G. Lewis, S. Cairns, C. Mackall, and G. Franchini Recombinant Interleukin-7 Induces Proliferation of Naive Macaque CD4+ and CD8+ T Cells In Vivo J. Virol., September 15, 2004; 78(18): 9740 - 9749. [Abstract] [Full Text] [PDF] A. V. Gulino, D. Moratto, S. Sozzani, P. Cavadini, K. Otero, L. Tassone, L. Imberti, S. Pirovano, L. D. Notarangelo, R. Soresina, et al. Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome Blood, July 15, 2004; 104(2): 444 - 452. [Abstract] [Full Text] [PDF] M. Lichterfeld, X. G. Yu, M. T. Waring, S. K. Mui, M. N. Johnston, D. Cohen, M. M. Addo, J. Zaunders, G. Alter, E. Pae, et al. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8+ T cells producing both interferon-{gamma} and tumor necrosis factor-{alpha} Blood, July 15, 2004; 104(2): 487 - 494. [Abstract] [Full Text] [PDF] A. Boissonnas, C. Combadiere, E. Lavergne, M. Maho, C. Blanc, P. Debre, and B. Combadiere Antigen Distribution Drives Programmed Antitumor CD8 Cell Migration and Determines Its Efficiency J. Immunol., July 1, 2004; 173(1): 222 - 229. [Abstract] [Full Text] [PDF] I. Kang, M. S. Hong, H. Nolasco, S. H. Park, J. M. Dan, J.-Y. Choi, and J. Craft Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine J. Immunol., July 1, 2004; 173(1): 673 - 681. [Abstract] [Full Text] [PDF] E. Mallard, F. Vernel-Pauillac, T. Velu, F. Lehmann, J.-P. Abastado, M. Salcedo, and N. Bercovici IL-2 Production by Virus- and Tumor-Specific Human CD8 T Cells Is Determined by Their Fine Specificity J. Immunol., March 15, 2004; 172(6): 3963 - 3970. [Abstract] [Full Text] [PDF] J. J. Obar, S. G. Crist, D. C. Gondek, and E. J. Usherwood Different Functional Capacities of Latent and Lytic Antigen-Specific CD8 T Cells in Murine Gammaherpesvirus Infection J. Immunol., January 15, 2004; 172(2): 1213 - 1219. [Abstract] [Full Text] [PDF] S. Cavalieri, S. Cazzaniga, M. Geuna, Z. Magnani, C. Bordignon, L. Naldini, and C. Bonini Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence Blood, July 15, 2003; 102(2): 497 - 505. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020