|
|
Prepublished online as a Blood First Edition Paper on January 30, 2003; DOI 10.1182/blood-2002-10-3236.
 Previous Article | Table of Contents | Next Article 
Blood, 1 June 2003, Vol. 101, No. 11, pp. 4539-4546
NEOPLASIA
MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma
Dolors Sanchez-Izquierdo,
Gerard Buchonnet,
Reiner Siebert,
Randy D. Gascoyne,
Joan Climent,
Loraine Karran,
Miguel Marin,
David Blesa,
Douglas Horsman,
Andreas Rosenwald,
Louis M. Staudt,
Donna G. Albertson,
Ming-Qing Du,
Hongtao Ye,
Peter Marynen,
Javier Garcia-Conde,
Daniel Pinkel,
Martin J. S. Dyer, and
Jose Angel Martinez-Climent
From the Department of Hematology and Medical Oncology, Hospital Clinico, University of Valencia, Spain; Department of Haematology, University of Leicester, Leicester, United Kingdom; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada; Metabolism Branch, National Cancer Institute, Bethesda, MD; Research Institute, University of California San Francisco, CA; Department of Histopathology, University College London, London, United Kingdom; and Center for Human Genetics-Flanders Interuniversity, Institute for Biotechnology, University of Leuven, Leuven, Belgium.
The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of mucosa-associated lymphoid tissue (MALT) lymphoma. Here, we show that deregulated MALT1 expression may occur in B-cell non-Hodgkin lymphoma (B-NHL) of various histologic subtypes either through translocation to the immunoglobulin heavy chain (IGH) locus or by genomic amplification. First, 2 cases, one case of MALT lymphoma and another of aggressive marginal zone lymphoma (MZL) with t(14;18)(q32;q21), cytogenetically identical to the translocation involving BCL2, were shown by fluorescence in situ hybridization (FISH) to involve MALT1, which lies about 5 Mb centromeric of BCL2. Molecular cloning of both by long-distance inverse polymerase chain reaction showed breakpoints lying 1 to 2 kilobase (kb) centromeric of the first 5' MALT1 exon; both cases showed MALT1 overexpression at either RNA or protein levels. Second, we examined the structure and gene expression profile of genomic amplifications involving 18q21 in a panel of 40 B-NHL cell lines using comparative genomic hybridization to microarrays (array CGH) and gene expression profiling techniques. Using array CGH, 2 peaks of genomic amplification were observed, one centered around BCL2 and the other around MALT1.Ofthe 3 cell lines with MALT1 amplification, 2 showed MALT1 overexpression as assessed by gene profiling, quantitative reverse transcription–polymerase chain reaction (QRT-PCR), and Western blotting. To determine if comparable events occurred in primary MALT and splenic MZL tumors, 40 cases were analyzed by FISH or QRT-PCR; genomic amplification and MALT1 overexpression were seen in 2 cases. Together, these data implicate MALT1 as a dominant oncogene that may play a role in the pathogenesis of B-NHL.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E C Obermann, M Csato, S Dirnhofer, and A Tzankov
BCL2 gene aberration as an IPI-independent marker for poor outcome in non-germinal-centre diffuse large B cell lymphoma
J. Clin. Pathol.,
October 1, 2009;
62(10):
903 - 907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Bende, F. van Maldegem, and C. J.M. van Noesel
Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas
Haematologica,
August 1, 2009;
94(8):
1109 - 1123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Takeuchi, H. Tagawa, A. Tsujikawa, M. Nakagawa, M. Katayama-Suguro, Y. Guo, and M. Seto
The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis
Haematologica,
January 1, 2009;
94(1):
61 - 69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Dierlamm, E. M. Murga Penas, S. Bentink, S. Wessendorf, H. Berger, M. Hummel, W. Klapper, D. Lenze, A. Rosenwald, E. Haralambieva, et al.
Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
Haematologica,
May 1, 2008;
93(5):
688 - 696.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhou, H. Ye, J. I. Martin-Subero, S. Gesk, R. Hamoudi, Y.-J. Lu, R. Wang, J. Shipley, R. Siebert, P. G. Isaacson, et al.
The pattern of genomic gains in salivary gland MALT lymphomas
Haematologica,
July 1, 2007;
92(7):
921 - 927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Noels, G. van Loo, S. Hagens, V. Broeckx, R. Beyaert, P. Marynen, and M. Baens
A Novel TRAF6 Binding Site in MALT1 Defines Distinct Mechanisms of NF-{kappa}B Activation by API2{middle dot}MALT1 Fusions
J. Biol. Chem.,
April 6, 2007;
282(14):
10180 - 10189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M Bacon, M.-Q. Du, and A. Dogan
Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists
J. Clin. Pathol.,
April 1, 2007;
60(4):
361 - 372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Mestre-Escorihuela, F. Rubio-Moscardo, J. A. Richter, R. Siebert, J. Climent, V. Fresquet, E. Beltran, X. Agirre, I. Marugan, M. Marin, et al.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
Blood,
January 1, 2007;
109(1):
271 - 280.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M-Q Du and J C Atherton
Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management.
Gut,
June 1, 2006;
55(6):
886 - 893.
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Sagaert, P. de Paepe, L. Libbrecht, V. Vanhentenrijk, G. Verhoef, J. Thomas, I. Wlodarska, and C. De Wolf-Peeters
Forkhead Box Protein P1 Expression in Mucosa-Associated Lymphoid Tissue Lymphomas Predicts Poor Prognosis and Transformation to Diffuse Large B-Cell Lymphoma
J. Clin. Oncol.,
June 1, 2006;
24(16):
2490 - 2497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Baens, S. Fevery, X. Sagaert, H. Noels, S. Hagens, V. Broeckx, A. D. Billiau, C. De Wolf-Peeters, and P. Marynen
Selective Expansion of Marginal Zone B Cells in E{micro}-API2-MALT1 Mice Is Linked to Enhanced I{kappa}B Kinase {gamma} Polyubiquitination.
Cancer Res.,
May 15, 2006;
66(10):
5270 - 5277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Dijkman, C. P. Tensen, E. S. Jordanova, J. Knijnenburg, J. J. Hoefnagel, A. A. Mulder, C. Rosenberg, A. K. Raap, R. Willemze, K. Szuhai, et al.
Array-Based Comparative Genomic Hybridization Analysis Reveals Recurrent Chromosomal Alterations and Prognostic Parameters in Primary Cutaneous Large B-Cell Lymphoma
J. Clin. Oncol.,
January 10, 2006;
24(2):
296 - 305.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nakagawa, Y. Hosokawa, M. Yonezumi, K. Izumiyama, R. Suzuki, S. Tsuzuki, M. Asaka, and M. Seto
MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10
Blood,
December 15, 2005;
106(13):
4210 - 4216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Farinha and R. D. Gascoyne
Molecular Pathogenesis of Mucosa-Associated Lymphoid Tissue Lymphoma
J. Clin. Oncol.,
September 10, 2005;
23(26):
6370 - 6378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Bertoni and E. Zucca
State-of-the-Art Therapeutics: Marginal-Zone Lymphoma
J. Clin. Oncol.,
September 10, 2005;
23(26):
6415 - 6420.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Zucca and F. Bertoni
Another Piece of the MALT Lymphomas Jigsaw
J. Clin. Oncol.,
August 1, 2005;
23(22):
4832 - 4834.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Rubio-Moscardo, J. Climent, R. Siebert, M. A. Piris, J. I. Martin-Subero, I. Nielander, J. Garcia-Conde, M. J. S. Dyer, M. J. Terol, D. Pinkel, et al.
Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome
Blood,
June 1, 2005;
105(11):
4445 - 4454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Ho, R. E. Davis, B. Conne, R. Chappuis, M. Berczy, P. Mhawech, L. M. Staudt, and J. Schwaller
MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-{kappa}B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells
Blood,
April 1, 2005;
105(7):
2891 - 2899.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tagawa, S. Tsuzuki, R. Suzuki, S. Karnan, A. Ota, Y. Kameoka, M. Suguro, K. Matsuo, M. Yamaguchi, M. Okamoto, et al.
Genome-Wide Array-Based Comparative Genomic Hybridization of Diffuse Large B-Cell Lymphoma: Comparison between CD5-Positive and CD5-Negative Cases
Cancer Res.,
September 1, 2004;
64(17):
5948 - 5955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hosokawa, H. Suzuki, Y. Suzuki, R. Takahashi, and M. Seto
Antiapoptotic Function of Apoptosis Inhibitor 2-MALT1 Fusion Protein Involved in t(11;18)(q21;q21) Mucosa-Associated Lymphoid Tissue Lymphoma
Cancer Res.,
May 15, 2004;
64(10):
3452 - 3457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Krugmann, A Tzankov, S Dirnhofer, F Fend, R Greil, R Siebert, and M Erdel
Unfavourable prognosis of patients with trisomy 18q21 detected by fluorescence in situ hybridisation in t(11;18) negative, surgically resected, gastrointestinal B cell lymphomas
J. Clin. Pathol.,
April 1, 2004;
57(4):
360 - 364.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Calin, C. Sevignani, C. D. Dumitru, T. Hyslop, E. Noch, S. Yendamuri, M. Shimizu, S. Rattan, F. Bullrich, M. Negrini, et al.
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
PNAS,
March 2, 2004;
101(9):
2999 - 3004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Wohlfart, D. Sebinger, P. Gruber, J. Buch, D. Polgar, G. Krupitza, M. Rosner, M. Hengstschlager, M. Raderer, A. Chott, et al.
FAS (CD95) Mutations Are Rare in Gastric MALT Lymphoma but Occur More Frequently in Primary Gastric Diffuse Large B-Cell Lymphoma
Am. J. Pathol.,
March 1, 2004;
164(3):
1081 - 1089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Schwaenen, M. Nessling, S. Wessendorf, T. Salvi, G. Wrobel, B. Radlwimmer, H. A. Kestler, C. Haslinger, S. Stilgenbauer, H. Dohner, et al.
Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations
PNAS,
January 27, 2004;
101(4):
1039 - 1044.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Streubel, D. Huber, S. Wohrer, A. Chott, and M. Raderer
Frequency of Chromosomal Aberrations Involving MALT1 in Mucosa-Associated Lymphoid Tissue Lymphoma in Patients with Sjogren's Syndrome
Clin. Cancer Res.,
January 15, 2004;
10(2):
476 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ghannam, A. Takeda, T. Camarata, M. A. Moore, A. Viale, and N. R. Yaseen
The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells
J. Biol. Chem.,
January 9, 2004;
279(2):
866 - 875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Pileri, P. L. Zinzani, P. Went, A. Pileri Jr, and M. Bendandi
Indolent lymphoma: the pathologist's viewpoint
Ann. Onc.,
January 1, 2004;
15(1):
12 - 18.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Albertson and D. Pinkel
Genomic microarrays in human genetic disease and cancer
Hum. Mol. Genet.,
October 15, 2003;
12(90002):
R145 - 152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Conconi, G. Martinelli, C. Thieblemont, A. J. M. Ferreri, L. Devizzi, F. Peccatori, M. Ponzoni, E. Pedrinis, S. Dell'Oro, G. Pruneri, et al.
Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type
Blood,
October 15, 2003;
102(8):
2741 - 2745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
