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Prepublished online as a Blood First Edition Paper on February 13, 2003; DOI 10.1182/blood-2002-12-3917. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-12-3917v1 101/12/4711    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ooi, J. Articles by Asano, S. Search for Related Content PubMed PubMed Citation Articles by Ooi, J. Articles by Asano, S. Related Collections Transplantation Brief Reports Clinical Trials and Observations Neoplasia Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 June 2003, Vol. 101, No. 12, pp. 4711-4713 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Brief report Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome Jun Ooi, Tohru Iseki, Satoshi Takahashi, Akira Tomonari, Koji Ishii, Kashiya Takasugi, Yoko Shimohakamada, Nobuhiro Ohno, Kaoru Uchimaru, Fumitaka Nagamura, Arinobu Tojo, and Shigetaka Asano From the Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Japan. We report the results of unrelated cord blood transplantation (CBT) for 13 adult patients with advanced myelodysplastic syndrome (MDS). The median age was 40 years, the median weight was 51 kg, and the median number of infused nucleated cells was 2.43 x 107/kg. Twelve patients had myeloid reconstitution, and the median time to more than 0.5 x 109/L (5 x 108/L) absolute neutrophil count was 22.5 days. A self-sustained platelet count more than 50 x 109/L was achieved in 11 patients at a median time of 49 days. Acute graft versus host disease (GVHD) occurred in 9 of 12 evaluable patients and chronic GVHD in 8 of 11 evaluable patients. Ten patients are alive and free of disease at between 171 and 1558 days after transplantation. The probability of disease-free survival at 2 years was 76.2%. These results suggest that adult advanced MDS patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Progress with unrelated cord blood transplants in adults Joanne Kurtzberg Blood 2003 101: 4648. [Full Text] [PDF] This article has been cited by other articles: S. Takahashi, J. Ooi, A. Tomonari, T. Konuma, N. Tsukada, M. Oiwa-Monna, K. Fukuno, M. Uchiyama, K. Takasugi, T. Iseki, et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen Blood, February 1, 2007; 109(3): 1322 - 1330. [Abstract] [Full Text] [PDF] Section on Hematology/Oncology and Section on Alle Cord Blood Banking for Potential Future Transplantation Pediatrics, January 1, 2007; 119(1): 165 - 170. [Abstract] [Full Text] [PDF] N. J. Chao Umbilical Cord Blood: Biology and Transplantation Am. Assoc. Cancer Res. Educ. Book, April 1, 2006; 2006(1): 329 - 333. [Full Text] [PDF] R. 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