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Prepublished online as a Blood First Edition Paper on January 23, 2003; DOI 10.1182/blood-2002-10-3229.
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Blood, 15 June 2003, Vol. 101, No. 12, pp. 4862-4869
IMMUNOBIOLOGY
Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells
Karsten Mahnke,
Yingjie Qian,
Jürgen Knop, and
Alexander H. Enk
From the Department of Dermatology, University of Mainz, Germany.
Coupling of ovalbumin (OVA) to anti–DEC-205 monoclonal antibody (mAb) ( DEC) induced the proliferation of OVA-specific T cells in vivo. Expansion was short-lived, caused by dendritic cells (DCs), and rendered T cells anergic thereafter. Phenotypic analysis revealed the induction of CD25+/CTLA-4+ T cells suppressing proliferation and interleukin-2 (IL-2) production of effector CD4+ T cells. The findings were supported by 2 disease models: (1) CD4+ T-cell–mediated hypersensitivity reactions were suppressed by the injection of DEC-OVA and (2) the application of hapten-coupled DEC-205 reduced CD8+ T-cell–mediated allergic reactions. Thus, targeting of antigens to immature DCs through DEC antibodies led to the induction of regulatory T cells, providing the basis for novel strategies to induce regulatory T cells in vivo.
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|
|
|
|
|
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|
|
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|
|
|
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|
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|
|
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175(9):
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919 - 929.
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[Full Text]
[PDF]
|
|
|
|
|
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|
|
|
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174(11):
7006 - 7013.
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[Full Text]
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|
|
|
|
|
|
|
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105(3):
1162 - 1169.
[Abstract]
[Full Text]
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|
|
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S. Vigouroux, E. Yvon, E. Biagi, and M. K. Brenner
Antigen-induced regulatory T cells
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July 1, 2004;
104(1):
26 - 33.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Salio, M. J. Palmowski, A. Atzberger, I. F. Hermans, and V. Cerundolo
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199(4):
567 - 579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Roelofs-Haarhuis, X. Wu, M. Nowak, M. Fang, S. Artik, and E. Gleichmann
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171(6):
2863 - 2872.
[Abstract]
[Full Text]
[PDF]
|
|
|
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