SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on February 13, 2003; DOI 10.1182/blood-2002-11-3392. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-11-3392v1 101/12/4887    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ranson, T. Articles by Di Santo, J. P. Search for Related Content PubMed PubMed Citation Articles by Ranson, T. Articles by Di Santo, J. P. Related Collections Immunobiology Apoptosis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 June 2003, Vol. 101, No. 12, pp. 4887-4893 IMMUNOBIOLOGY IL-15 is an essential mediator of peripheral NK-cell homeostasis Thomas Ranson, Christian A. J. Vosshenrich, Erwan Corcuff, Odile Richard, Werner Müller, and James P. Di Santo From the Unité des Cytokines et Développement Lymphoïde, Institut Pasteur, Paris, France; and GBF-Braunschweig, Germany. Several distinct classes of surface receptors can, on ligand binding, transmit signals that modulate the survival, proliferation, and apoptosis of peripheral B, T, and natural killer (NK) cells. At the population level, dynamic changes in lymphocyte cell numbers are strictly regulated to maintain a steady state, a process referred to as homeostasis. Although several studies have investigated the signals that regulate B- and T-cell homeostasis, little is known about the mechanisms that control the survival and proliferation of peripheral NK cells. Using an adoptive transfer system, we have investigated the role of c-dependent cytokines, in particular interleukin 7 (IL-7) and IL-15, and major histocompatibility complex (MHC) class I molecules in peripheral NK-cell homeostasis. We observed that IL-15 plays a dominant role in the survival of peripheral NK cells, via maintenance of the antiapoptotic factor Bcl-2. IL-15 availability, however, also plays an important role because endogenous NK cells in the recipient mice influence the behavior of adoptively transferred NK cells. Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Chiossone, J. Chaix, N. Fuseri, C. Roth, E. Vivier, and T. Walzer Maturation of mouse NK cells is a 4-stage developmental program Blood, May 28, 2009; 113(22): 5488 - 5496. [Abstract] [Full Text] [PDF] D. L. Hodge, J. Yang, M. D. Buschman, P. M. Schaughency, H. Dang, W. Bere, Y. Yang, R. Savan, J. J. Subleski, X.-M. Yin, et al. Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias Cancer Res., May 1, 2009; 69(9): 3986 - 3994. [Abstract] [Full Text] [PDF] I.-K. Park, C. Giovenzana, T. L. Hughes, J. Yu, R. Trotta, and M. A. Caligiuri The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development Blood, March 12, 2009; 113(11): 2470 - 2477. [Abstract] [Full Text] [PDF] J. D. French, C. L. Roark, W. K. Born, and R. L. O'Brien {gamma}{delta} T Lymphocyte Homeostasis Is Negatively Regulated by {beta}2-Microglobulin J. Immunol., February 15, 2009; 182(4): 1892 - 1900. [Abstract] [Full Text] [PDF] M. Cheng, H. N. Charoudeh, P. Brodin, Y. Tang, T. Lakshmikanth, P. Hoglund, S. E. W. Jacobsen, and E. Sitnicka Distinct and Overlapping Patterns of Cytokine Regulation of Thymic and Bone Marrow-Derived NK Cell Development J. Immunol., February 1, 2009; 182(3): 1460 - 1468. [Abstract] [Full Text] [PDF] M. Terabe, Y. Tagaya, Q. Zhu, L. Granger, M. Roederer, T. A. Waldmann, and J. A. Berzofsky IL-15 Expands Unconventional CD8{alpha}{alpha}NK1.1+ T Cells but Not V{alpha}14J{alpha}18+ NKT Cells J. Immunol., June 1, 2008; 180(11): 7276 - 7286. [Abstract] [Full Text] [PDF] M. Terme, N. Chaput, B. Combadiere, A. Ma, T. Ohteki, and L. Zitvogel Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells J. Immunol., April 1, 2008; 180(7): 4679 - 4686. [Abstract] [Full Text] [PDF] N. K. Gabler and M. E. Spurlock Integrating the immune system with the regulation of growth and efficiency J Anim Sci, April 1, 2008; 86(14_suppl): E64 - E74. [Abstract] [Full Text] [PDF] K. Pilbeam, P. Basse, L. Brossay, N. Vujanovic, R. Gerstein, A. N. Vallejo, and L. Borghesi The Ontogeny and Fate of NK Cells Marked by Permanent DNA Rearrangements J. Immunol., February 1, 2008; 180(3): 1432 - 1441. [Abstract] [Full Text] [PDF] C. A.J. Vosshenrich, S. Lesjean-Pottier, M. Hasan, O. Richard-Le Goff, E. Corcuff, O. Mandelboim, and J. P. Di Santo CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells J. Exp. Med., October 29, 2007; 204(11): 2569 - 2578. [Abstract] [Full Text] [PDF] G. X. Masse, E. Corcuff, H. Strick-Marchand, D. Guy-Grand, A. Tafuri-Bladt, M. L. Albert, O. Lantz, and J. P. Di Santo {gamma}c cytokines condition the progressive differentiation of CD4+ T cells PNAS, September 25, 2007; 104(39): 15442 - 15447. [Abstract] [Full Text] [PDF] M. Prlic, D. Kamimura, and M. J. Bevan Rapid generation of a functional NK-cell compartment Blood, September 15, 2007; 110(6): 2024 - 2026. [Abstract] [Full Text] [PDF] L. Chiossone, C. Vitale, F. Cottalasso, S. Moretti, B. Azzarone, L. Moretta, and M. C. Mingari Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells Blood, May 1, 2007; 109(9): 3767 - 3775. [Abstract] [Full Text] [PDF] N. D. Huntington, H. Tabarias, K. Fairfax, J. Brady, Y. Hayakawa, M. A. Degli-Esposti, M. J. Smyth, D. M. Tarlinton, and S. L. Nutt NK Cell Maturation and Peripheral Homeostasis Is Associated with KLRG1 Up-Regulation J. Immunol., April 15, 2007; 178(8): 4764 - 4770. [Abstract] [Full Text] [PDF] A. R. Rodriguez, B. P. Arulanandam, V. L. Hodara, H. M. McClure, E. K. Cobb, M. T. Salas, R. White, and K. K. Murthy Influence of interleukin-15 on CD8+ natural killer cells in human immunodeficiency virus type 1-infected chimpanzees J. Gen. Virol., February 1, 2007; 88(2): 641 - 651. [Abstract] [Full Text] [PDF] K. Nakazato, H. Yamada, T. Yajima, Y. Kagimoto, H. Kuwano, and Y. Yoshikai Enforced Expression of Bcl-2 Partially Restores Cell Numbers but Not Functions of TCR{gamma}{delta} Intestinal Intraepithelial T Lymphocytes in IL-15-Deficient Mice J. Immunol., January 15, 2007; 178(2): 757 - 764. [Abstract] [Full Text] [PDF] M. Katsuta, Y. Takigawa, M. Kimishima, M. Inaoka, R. Takahashi, and T. Shiohara NK Cells and {gamma}{delta}+ T Cells Are Phenotypically and Functionally Defective due to Preferential Apoptosis in Patients with Atopic Dermatitis. J. Immunol., June 15, 2006; 176(12): 7736 - 7744. [Abstract] [Full Text] [PDF] T. Bianchi, S. Gasser, A. Trumpp, and H. R. MacDonald c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis Blood, May 15, 2006; 107(10): 3992 - 3999. [Abstract] [Full Text] [PDF] S. K. Jacobi, N. K. Gabler, K. M. Ajuwon, J. E. Davis, and M. E. Spurlock Adipocytes, myofibers, and cytokine biology: New horizons in the regulation of growth and body composition J Anim Sci, April 1, 2006; 84(13_suppl): E140 - E. [Abstract] [Full Text] [PDF] M. Bajenoff, B. Breart, A. Y.C. Huang, H. Qi, J. Cazareth, V. M. Braud, R. N. Germain, and N. Glaichenhaus Natural killer cell behavior in lymph nodes revealed by static and real-time imaging J. Exp. Med., March 20, 2006; 203(3): 619 - 631. [Abstract] [Full Text] [PDF] J. D. French, C. L. Roark, W. K. Born, and R. L. O'Brien {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells PNAS, October 11, 2005; 102(41): 14741 - 14746. [Abstract] [Full Text] [PDF] F. Stevenaert, K. Van Beneden, V. De Colvenaer, A. S. Franki, V. Debacker, T. Boterberg, D. Deforce, K. Pfeffer, J. Plum, D. Elewaut, et al. Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-{beta} receptor expression Blood, August 1, 2005; 106(3): 956 - 962. [Abstract] [Full Text] [PDF] C. A. J. Vosshenrich, T. Ranson, S. I. Samson, E. Corcuff, F. Colucci, E. E. Rosmaraki, and J. P. Di Santo Roles for Common Cytokine Receptor {gamma}-Chain-Dependent Cytokines in the Generation, Differentiation, and Maturation of NK Cell Precursors and Peripheral NK Cells in Vivo J. Immunol., February 1, 2005; 174(3): 1213 - 1221. [Abstract] [Full Text] [PDF] M. Conklyn, C. Andresen, P. Changelian, and E. Kudlacz The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing J. Leukoc. Biol., December 1, 2004; 76(6): 1248 - 1255. [Abstract] [Full Text] [PDF] K. M. Ajuwon and M. E. Spurlock Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R608 - R611. [Abstract] [Full Text] [PDF] E. J. Kerschen, D. A. Cohen, A. M. Kaplan, and S. C. Straley The Plague Virulence Protein YopM Targets the Innate Immune Response by Causing a Global Depletion of NK Cells Infect. Immun., August 1, 2004; 72(8): 4589 - 4602. [Abstract] [Full Text] [PDF] S. H. Robbins, M. S. Tessmer, T. Mikayama, and L. Brossay Expansion and Contraction of the NK Cell Compartment in Response to Murine Cytomegalovirus Infection J. Immunol., July 1, 2004; 173(1): 259 - 266. [Abstract] [Full Text] [PDF] E. Assier, V. Jullien, J. Lefort, J.-L. Moreau, J. P. Di Santo, B. B. Vargaftig, J. R. Lapa e Silva, and J. Theze NK Cells and Polymorphonuclear Neutrophils Are Both Critical for IL-2-Induced Pulmonary Vascular Leak Syndrome J. Immunol., June 15, 2004; 172(12): 7661 - 7668. [Abstract] [Full Text] [PDF] S. I. Samson, S. Memet, C. A. J. Vosshenrich, F. Colucci, O. Richard, D. Ndiaye, A. Israel, and J. P. Di Santo Combined deficiency in I{kappa}B{alpha} and I{kappa}B{epsilon} reveals a critical window of NF-{kappa}B activity in natural killer cell differentiation Blood, June 15, 2004; 103(12): 4573 - 4580. [Abstract] [Full Text] [PDF] K. S. Schluns, E. C. Nowak, A. Cabrera-Hernandez, L. Puddington, L. Lefrancois, and H. L. Aguila Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor {alpha} expression PNAS, April 13, 2004; 101(15): 5616 - 5621. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020