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Blood, 15 January 2003, Vol. 101, No. 2, pp. 433-440
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HGAL is a novel interleukin-4-inducible gene that
strongly predicts survival in diffuse large B-cell
lymphoma
Izidore S. Lossos,
Ash A. Alizadeh,
Ranjani Rajapaksa,
Robert Tibshirani, and
Ronald Levy
From the Division of Oncology, Department of Medicine
and the Department of Health Research and Policy, Stanford University
School of Medicine, CA.
We have cloned and characterized a novel human gene,
HGAL (human germinal center-associated lymphoma),
which predicts outcome in patients with diffuse large B-cell
lymphoma (DLBCL). The HGAL gene comprises 6 exons and
encodes a cytoplasmic protein of 178 amino acids that contains an
immunoreceptor tyrosine-based activation motif (ITAM). It is highly
expressed in germinal center (GC) lymphocytes and GC-derived lymphomas
and is homologous to the mouse GC-specific gene M17.
Expression of the HGAL gene is specifically induced in B
cells by interleukin-4 (IL-4). Patients with DLBCL expressing high
levels of HGAL mRNA demonstrate significantly longer overall survival
than do patients with low HGAL expression. This association was
independent of the clinical international prognostic index. High HGAL
mRNA expression should be used as a prognostic factor in DLBCL.
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