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Prepublished online as a Blood First Edition Paper on September 12, 2002; DOI 10.1182/blood-2002-05-1592.
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Blood, 15 January 2003, Vol. 101, No. 2, pp. 706-710
NEOPLASIA
Brief report
Frequent occurrence of BCL6 rearrangements in nodular
lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin
lymphoma
Iwona Wlodarska,
Peet Nooyen,
Brigitte Maes,
José I. Martín-Subero,
Reiner Siebert,
Patrick Pauwels,
Chris De
Wolf-Peeters, and
Anne Hagemeijer
From the Center for Human Genetics, Catholic University
of Leuven, Leuven, Belgium; the Department of Pathology, Stichting
PAMM, Eindhoven, the Netherlands; the Division for Morphology and
Molecular Pathology, Catholic University of Leuven, Leuven, Belgium;
and the Institute of Human Genetics, University Hospital, Kiel,
Germany.
We studied the genomic status of BCL6 in 23 cases of
nodular lymphocyte predominance Hodgkin lymphoma (NLPHL) and 40 cases of classical Hodgkin lymphoma (cHL), using dual-color interphase fluorescence in situ hybridization (FISH). The BCL6
rearrangement was identified in 48% of NLPHL cases and was not
detected in cHL cases. As a confirmation, sequential or simultaneous
immunohistochemistry (IHC) and FISH using CD20 or BCL6
antibodies and BCL6 DNA probes was performed in 8 NLPHL
cases. The BCL6-associated translocations, t(3;22)(q27;q11), t(3;7)(q27;p12), and the most probable
t(3;9)(q27;p13), were identified in 3 cases. A consistent
expression of BCL6 protein in popcorn cells with the highest number of
intensely stained cells in cases with a genomic BCL6
rearrangement was shown by IHC. These findings support the hypothesis
of a germinal center B cell-derived origin of NLPHL, indicate a
significant role of BCL6 in the pathogenesis of NLPHL, and
provide further evidence of the genetic diversity underlying the
pathogenesis of NLPHL and cHL.
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