|
|
Prepublished online as a Blood First Edition Paper on October 3, 2002; DOI 10.1182/blood-2002-05-1505.
 Previous Article | Table of Contents | Next Article 
Blood, 1 February 2003, Vol. 101, No. 3, pp. 1164-1171
PHAGOCYTES
Expression of the inhibitor of apoptosis (IAP) family members in
human neutrophils: up-regulation of cIAP2 by granulocyte
colony-stimulating factor and overexpression of cIAP2 in chronic
neutrophilic leukemia
Taro Hasegawa,
Kenichi Suzuki,
Chikahiko Sakamoto,
Kensuke Ohta,
Saori Nishiki,
Masayuki Hino,
Noriyuki Tatsumi, and
Seiichi Kitagawa
From the Departments of Physiology and Clinical
Hematology, Osaka City University Medical School, Japan.
Human neutrophils were found to express members of the inhibitor of
apoptosis (IAP) family, namely cellular IAP1 (cIAP1), cIAP2, and
X-linked IAP. Among these members, cIAP2 expression was selectively
up-regulated by stimulation with granulocyte colony-stimulating factor
(G-CSF), but not with granulocyte-macrophage CSF. The increased expression of cIAP2 mRNA was detected as early as 30 minutes after in
vitro stimulation with G-CSF, and the elevated level of cIAP2 protein
was detected at 1 hour. The elevated level of cIAP2 protein was also
detected in peripheral blood neutrophils obtained from healthy donors
receiving G-CSF administration. G-CSF-induced up-regulation of cIAP2
mRNA and protein, phosphorylation of signal transducer and activator of
transcription 3 (STAT3), and the antiapoptotic effects were inhibited
by pretreatment of cells with AG490, a specific inhibitor of Janus
kinase 2 (JAK2). Mature neutrophils from a patient with chronic
neutrophilic leukemia exhibited remarkable overexpression of cIAP2 mRNA
and prolongation of survival, whereas cIAP2 mRNA expression and
survival in mature neutrophils from patients with chronic myelogenous
leukemia were essentially similar to those in normal neutrophils. These
findings suggest that cIAP2 expression is up-regulated by
G-CSF through activation of the JAK2-STAT3 pathway, and increased
expression of cIAP2 protein may contribute to G-CSF-mediated
antiapoptosis. In addition, overexpression of cIAP2 may be partly
responsible for sustained neutrophilia at least in some cases of
chronic neutrophilic leukemia.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
B. J. van Raam, A. Drewniak, V. Groenewold, T. K. van den Berg, and T. W. Kuijpers
Granulocyte colony-stimulating factor delays neutrophil apoptosis by inhibition of calpains upstream of caspase-3
Blood,
September 1, 2008;
112(5):
2046 - 2054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. T. Lam, G. Wright, R. E. Davis, G. Lenz, P. Farinha, L. Dang, J. W. Chan, A. Rosenwald, R. D. Gascoyne, and L. M. Staudt
Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma
Blood,
April 1, 2008;
111(7):
3701 - 3713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Cho, S. H. Lee, K. R. Kim, H. M. Lee, S. H. Lee, and T. H. Kim
Expression and Distributional Patterns of the Inhibitor of Apoptosis Protein Family and Caspase 3 in Nasal Polyps
Arch Otolaryngol Head Neck Surg,
March 1, 2008;
134(3):
316 - 321.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hu, Y. Shikama, I. Matsuoka, and J. Kimura
Terminally differentiated neutrophils predominantly express Survivin-2{alpha}, a dominant-negative isoform of Survivin
J. Leukoc. Biol.,
February 1, 2008;
83(2):
393 - 400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sekikawa, H. Fukui, S. Fujii, K. Ichikawa, S. Tomita, J. Imura, T. Chiba, and T. Fujimori
REG I{alpha} protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells
Carcinogenesis,
January 1, 2008;
29(1):
76 - 83.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Weisberg, A. L. Kung, R. D. Wright, D. Moreno, L. Catley, A. Ray, L. Zawel, M. Tran, J. Cools, G. Gilliland, et al.
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells
Mol. Cancer Ther.,
July 1, 2007;
6(7):
1951 - 1961.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mishra, J. P. Mishra, and A. Kumar
Activation of JNK-dependent Pathway Is Required for HIV Viral Protein R-induced Apoptosis in Human Monocytic Cells: INVOLVEMENT OF ANTIAPOPTOTIC BCL2 AND c-IAP1 GENES
J. Biol. Chem.,
February 16, 2007;
282(7):
4288 - 4300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Chauhan, P. Neri, M. Velankar, K. Podar, T. Hideshima, M. Fulciniti, P. Tassone, N. Raje, C. Mitsiades, N. Mitsiades, et al.
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)
Blood,
February 1, 2007;
109(3):
1220 - 1227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mishra, J. P. Mishra, K. Gee, D. C. McManus, E. C. LaCasse, and A. Kumar
Distinct Role of Calmodulin and Calmodulin-dependent Protein Kinase-II in Lipopolysaccharide and Tumor Necrosis Factor-{alpha}-mediated Suppression of Apoptosis and Antiapoptotic c-IAP2 Gene Expression in Human Monocytic Cells
J. Biol. Chem.,
November 11, 2005;
280(45):
37536 - 37546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Sakamoto, F. Hato, T. Kato, C. Sakamoto, M. Akahori, M. Hino, and S. Kitagawa
Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2
J. Leukoc. Biol.,
July 1, 2005;
78(1):
301 - 309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Hu and M. M. Sayeed
Activation of PI3-kinase/PKB contributes to delay in neutrophil apoptosis after thermal injury
Am J Physiol Cell Physiol,
May 1, 2005;
288(5):
C1171 - C1178.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Li, R. M. Thomas, H. Suzuki, J. K. De Brabander, X. Wang, and P. G. Harran
A Small Molecule Smac Mimic Potentiates TRAIL- and TNF{alpha}-Mediated Cell Death
Science,
September 3, 2004;
305(5689):
1471 - 1474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kato, E. Sakamoto, H. Kutsuna, A. Kimura-Eto, F. Hato, and S. Kitagawa
Proteolytic Conversion of STAT3{alpha} to STAT3{gamma} in Human Neutrophils: ROLE OF GRANULE-DERIVED SERINE PROTEASES
J. Biol. Chem.,
July 23, 2004;
279(30):
31076 - 31080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Maianski, D. Roos, and T. W. Kuijpers
Bid Truncation, Bid/Bax Targeting to the Mitochondria, and Caspase Activation Associated with Neutrophil Apoptosis Are Inhibited by Granulocyte Colony-Stimulating Factor
J. Immunol.,
June 1, 2004;
172(11):
7024 - 7030.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nishiki, F. Hato, N. Kamata, E. Sakamoto, T. Hasegawa, A. Kimura-Eto, M. Hino, and S. Kitagawa
Selective activation of STAT3 in human monocytes stimulated by G-CSF: implication in inhibition of LPS-induced TNF-{alpha} production
Am J Physiol Cell Physiol,
June 1, 2004;
286(6):
C1302 - C1311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Altznauer, S. Martinelli, S. Yousefi, C. Thurig, I. Schmid, E. M. Conway, M. H. Schoni, P. Vogt, C. Mueller, M. F. Fey, et al.
Inflammation-associated Cell Cycle-independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils
J. Exp. Med.,
May 17, 2004;
199(10):
1343 - 1354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Wang, X. Wang, and B. M. Evers
Induction of cIAP-2 in Human Colon Cancer Cells through PKC{delta}/NF-{kappa}B
J. Biol. Chem.,
December 19, 2003;
278(51):
51091 - 51099.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
